Osteoblasts infill irregular pores under curvature and porosity controls: a hypothesis-testing analysis of cell behaviours

Biomechanics and Modeling in Mechanobiology
Mohd Almie Alias, Pascal R Buenzli

Abstract

The geometric control of bone tissue growth plays a significant role in bone remodelling, age-related bone loss, and tissue engineering. However, how exactly geometry influences the behaviour of bone-forming cells remains elusive. Geometry modulates cell populations collectively through the evolving space available to the cells, but it may also modulate the individual behaviours of cells. To factor out the collective influence of geometry and gain access to the geometric regulation of individual cell behaviours, we develop a mathematical model of the infilling of cortical bone pores and use it with available experimental data on cortical infilling rates. Testing different possible modes of geometric controls of individual cell behaviours consistent with the experimental data, we find that efficient smoothing of irregular pores only occurs when cell secretory rate is controlled by porosity rather than curvature. This porosity control suggests the convergence of a large scale of intercellular signalling to single bone-forming cells, consistent with that provided by the osteocyte network in response to mechanical stimulus. After validating the mathematical model with the histological record of a real cortical pore infilling, we ex...Continue Reading

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Citations

Nov 15, 2019·International Journal for Numerical Methods in Biomedical Engineering·Mohd Almie Alias, Pascal R Buenzli
Mar 6, 2021·Journal of Theoretical Biology·Solene G D Hegarty-CremerPascal R Buenzli
Aug 7, 2021·Journal of Theoretical Biology·Alexander P BrowningMatthew J Simpson

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