Osteocalcin- and osteopontin-containing neurons in the rat hind brain.

Cellular and Molecular Neurobiology
Toshihiko SuzukiH Ichikawa

Abstract

Immunohistochemistry for osteocalcin (OC) and osteopontin (OPN) was performed to know their distributions in the hind brain of adult rats. OC- and OPN-immunoreactivity (-ir) were detected in neuronal cell bodies, including perikarya and proximal dendrites and the neuropil. In the cranial nerve motor nuclei, numerous OC- and OPN-immunoreactive (-ir) neurons were detected. The neuropil in the cranial motor nuclei mostly showed strong OC- and OPN-staining intensity. The cranial nerve sensory nuclei and other relay and modulating structures in the lower brain stem also contained various numbers of OC- and OPN-ir neurons. The staining intensities in the neuropil were varied among these regions. In the cerebellar cortex, Purkinje cells and granule cells showed OPN-ir but not OC-ir. However, OC- and OPN-ir neurons were abundantly distributed throughout the cerebellar nuclei. The neuropil in the cerebellar nuclei showed moderate OC-ir and strong OPN-ir staining intensities. These findings indicate that the distribution patterns of OC- and OPN-ir neurons were similar in many structures within the hind brain. OC may play a role in modulating neuroprotective function of OPN.

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Citations

Jan 19, 2016·Journal of Diabetes and Its Complications·Raelene E MaserP Babu Balagopal
Jul 1, 2016·Somatosensory & Motor Research·Naoya HashimotoHiroyuki Ichikawa
Sep 7, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Tadasu SatoHiroyuki Ichikawa

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