PMID: 8593206Aug 1, 1995Paper

Osteocalcin expression in primary bone tumors--in situ hybridization and immunohistochemical study

Journal of Korean Medical Science
Y K ParkH R Park

Abstract

Osteocalcin is one of the most abundant noncollagenous proteins found in adult bone. It is a highly conserved gamma-carboxyglutamic acid-containing protein that is believed to be produced exclusively by osteoblasts. In this study, intracellular and extracellular localization of osteocalcin in osteosarcoma was examined with anti-osteocalcin antibody and in situ hybridization using a synthetic oligonucleotide. Immunohistochemically, osteoblastic osteosarcomas were all positive for osteocalcin. The chondroblastic osteosarcomas were positive on the neoplastic chondrocytes. The five fibroblastic osteosarcomas out of seven were positive for osteocalcin immunostaining over the neoplastic spindle cells. Five cases of osteoblastic osteosarcomas out of seven were positive for osteocalcin in situ hybridization. Two cases of chondroblastic osteosarcomas and three cases of fibroblastic osteosarcomas were positive for in situ demonstration of osteocalcin. The malignant tumor giant cells were positive for osteocalcin immunostaining 83%. They were also positive for in situ hybridization. The benign giant cells in five giant cell tumors and five aneurysmal bone cysts were negative for osteocalcin immunostaining. The benign giant cells in three ...Continue Reading

Citations

Dec 1, 2011·Surgical Pathology Clinics·Samir K El-MoftyRebecca D Chernock
Oct 20, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Larissa Santana Arantes EliasElismauro Francisco Mendonça
Jul 21, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Allisson Filipe Lopes MartinsElismauro Francisco Mendonça
Jul 1, 2009·Journal of Periodontology·Hatice HasturkAlpdogan Kantarci
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hatice HasturkThomas E Van Dyke
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