Osteocalcin is independently associated with body mass index in adolescent girls

Pediatric Obesity
G Dubnov-RazN W Constantini

Abstract

Osteocalcin is a bone-related protein, recently found to correlate with body mass index (BMI), waist circumference, fat percentage and metabolic syndrome in adults. The aim of this study was to determine the relationship between osteocalcin and BMI in adolescence, a time of significant bone accrual, while considering possible confounders related to bone and body composition. We analyzed data from 160 female adolescents (mean age 15.1 ± 0.7 years), which were divided into tertiles by osteocalcin levels. Across these three groups, we examined the differences in BMI with relation to age, total daily energy intake, calcium intake, physical activity (PA), total body bone mineral density, parathyroid hormone (PTH), 25(OH)-vitamin D, bone alkaline phosphatase and body fat percentage. Mean BMI values differed significantly between participants in the three osteocalcin tertiles, including after adjustment for age, PA, PTH, energy and calcium intakes. Post-hoc analysis revealed that girls in the highest osteocalcin tertile, had a significantly lower BMI than those in the two lower ones (19.3 ± 2.2 vs. 20.6 ± 3.0 and 20.7 ± 2.9 kg m(-2), respectively, P = 0.018). There was no significant difference in energy and calcium intakes, bone mine...Continue Reading

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Citations

Jul 6, 2014·Canadian Journal of Diabetes·Negar TabatabaeiHope A Weiler
Jun 27, 2014·European Journal of Dentistry·Zohreh Hedayati, Yunes Nazari Dashlibrun
Aug 22, 2018·Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research·Harleen Kaur SoniMansi Vasavada
Dec 19, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Michael M SchündelnCorinna Grasemann
Mar 6, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Jaak JürimäeToivo Jürimäe
Dec 3, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L N MoscaJ E Corrente
Jun 4, 2014·Archives of Biochemistry and Biophysics·Mathieu Ferron, Julie Lacombe

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