Osteocalcin is inversely associated with adiposity and leptin in adolescent boys

Journal of Pediatric Endocrinology & Metabolism : JPEM
J JürimäeT Jürimäe

Abstract

Recently, osteocalcin (OC), an osteoblast-derived hormone, has been found to correlate with adiposity, adipocytokines and insulin resistance in adults, but few studies have investigated this in children. The aim of this study was to investigate these associations in adolescent boys, for whom it is a time of significant bone mineral accrual, taking into account possible confounders related to adipose and bone tissues. Participants were 141 adolescent boys (mean age 13.9±0.7 years), who were divided into tertiles according to OC levels. Across these groups, differences in total body fat mass (FM), body fat distribution, adiponectin, leptin and insulin resistance values were examined with relation to age, pubertal stage, daily energy and calcium intakes, and physical activity. Mean body mass index (BMI), FM, body fat% and leptin differed significantly between subjects in the three OC tertiles after adjustment for age, pubertal stage, energy and calcium intakes, and physical activity. There were no differences in fat free mass (FFM), bone mineral content, energy and calcium intakes, physical activity, adiponectin and insulin resistance values between study groups. For the entire cohort, mean serum OC was 130.2±45.2 ng/mL and was re...Continue Reading

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Citations

Aug 10, 2018·The Tohoku Journal of Experimental Medicine·Won Young LeeKee-Hyoung Lee
Apr 8, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Donvina VaitkeviciuteJaak Jürimäe
Dec 19, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Michael M SchündelnCorinna Grasemann
Jul 8, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·Junji TakayaKazunari Kaneko
Jun 30, 2019·Nutrients·Jaak JürimäeVallo Tillmann

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