Osteochondral defects of the talus with a focus on platelet-rich plasma as a potential treatment option: a review

BMJ Open Sport & Exercise Medicine
Ahmed Aly ElghawyMichael Rosselli

Abstract

To provide a review of osteochondral lesions of the talus, to discuss the evidence of the risks and benefits of platelet-rich plasma (PRP) as a viable treatment option, and to measure the efficacy of PRP using MRI evidence of cartilage regeneration, as well as scales that measure improvement in 'pain' and 'functionality'. Studies that use PRP in either conservative or intraoperative settings to treat osteochondral defects of the talus. There are seven studies that compare hyaluronic acid or standard surgical options against PRP in treating osteochondral lesions of the talus. Five studies use PRP as supplemental treatment in intraoperative settings, while two studies use PRP conservatively as intra-articular injections. There were minimal adverse effects. Pain and functionality scores consistently improved in those who underwent PRP treatments over the course of 4 years. MRI showed significant but inconsistent results in chondral regeneration. PRP may show clinical benefit in those with osteochondral lesions of the talus in terms of pain and functionality, although chondral regeneration via MRI is inconsistent. Limitations include the small sample sizes in these seven studies, as well as no standardised formula for PRP preparati...Continue Reading

References

May 27, 1999·Annals of the Rheumatic Diseases·D E Shepherd, B B Seedhom
Dec 28, 1999·Foot & Ankle International·S HeppleD Glew
Mar 1, 1996·The Journal of the American Academy of Orthopaedic Surgeons·J W Stone
Aug 30, 2008·The American Journal of Sports Medicine·Richard D FerkelRyan M Dopirak
May 19, 2009·Clinical Orthopaedics and Related Research·Sandro GianniniBrunella Grigolo
Oct 31, 2009·The American Journal of Sports Medicine·Timothy E FosterScott A Rodeo
May 21, 2010·Foot and Ankle Surgery : Official Journal of the European Society of Foot and Ankle Surgeons·Suraj JoshyKarthik Hariharan
Jan 19, 2012·The American Journal of Sports Medicine·Omer Mei-DanMeir Nyska
Dec 12, 2012·The American Journal of Sports Medicine·Sandro GianniniFrancesca Vannini
May 9, 2013·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Chayanin AngthongWirana Angthong
Nov 30, 2013·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Amir KhoshbinJaskarndip Chahal
Jan 22, 2015·Joints·Giacomo ZanonMatteo Marullo
Sep 8, 2016·Joints·Francesca VanniniMassimiliano Mosca
Oct 7, 2016·The Journal of Bone and Joint Surgery. American Volume·Nkemakolam EgekezeMark Bernhardt

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Citations

Jun 26, 2018·Expert Opinion on Biological Therapy·Isabel Andia, Nicola Maffulli
Sep 15, 2020·Current Sports Medicine Reports·William H WestChristopher R Gordon
Feb 2, 2021·The Bone & Joint Journal·Eoghan T HurleyArul Ramasamy

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BETA
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