Osteochondral regeneration by a bilayered construct in a cell-free or cell-based approach

Biotechnology Letters
Zheng CaoJunjun Tang

Abstract

A bilayered construct with or without adipose-derived stem cells (ASCs) was applied to repair full-thickness defects in the patellar groove of 18 rabbits. Non-treated and treated defects were divided into three groups: a control group (n = 12), a cell-free group (n = 12) and a cell-based group (n = 12). Histological appearance and grading were evaluated at 8 and 12 weeks. At 12 weeks, osteochondral-like tissues completely filled in the defects and integrated with host tissues in the cell-based group. The semi-quantitative score of the cell-based group (4.2 ± 1.2), which is a total score ranging from 0 (best) to 20 (worst), was significantly better than that of the other two groups (cell-free: 13.8 ± 2.5; control: 10.3 ± 2.4). This finding indicated that the bilayered constructs combined with ASCs could be an effective way to enhance osteochondral regeneration.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M R UristA Lietze
Feb 16, 2000·Biomaterials·J S Temenoff, A G Mikos
Mar 3, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Long BiRong Lv
Oct 11, 2008·Tissue Engineering. Part B, Reviews·Timothy M O'Shea, Xigeng Miao
Nov 18, 2008·Sports Medicine and Arthroscopy Review·Allison G McNickleBrian J Cole
Jun 11, 2009·Seminars in Cell & Developmental Biology·Sarah Sundelacruz, David L Kaplan
Oct 23, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dan QuLin Cheng
Sep 29, 2011·Journal of Tissue Engineering and Regenerative Medicine·Limin WangMichael S Detamore

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Citations

Apr 4, 2014·Journal of the Royal Society, Interface·June E JeonDietmar W Hutmacher
Jan 31, 2014·Tissue Engineering. Part a·Silvia Lopa, Henning Madry
Dec 3, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·June E JeonDietmar W Hutmacher
Oct 28, 2014·Journal of Biomedical Materials Research. Part a·Azizeh-Mitra YousefiNicholas Uth
Dec 7, 2013·BioMed Research International·Marta BarbaWanda Lattanzi
Apr 5, 2017·Expert Opinion on Biological Therapy·Marta BarbaWanda Lattanzi
Apr 12, 2018·Annual Review of Biomedical Engineering·Edward D Bonnevie, Robert L Mauck
Nov 17, 2021·ACS Biomaterials Science & Engineering·Carlos Pitta KruizeMohammad J Mirzaali

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