Osteochondritis Dissecans of the Knee: Etiology and Pathogenetic Mechanisms. A Systematic Review.

Cartilage
Luca AndrioloGiuseppe Filardo

Abstract

The purpose of this manuscript is to analyze the evidence regarding etiopathogenesis of knee osteochondritis dissecans (OCD) lesions through a systematic review, so to summate the current understanding of the origin and progression of this pathologic articular processes. A systematic review of the literature was performed on the PubMed and Cochrane databases on October 2017 by 2 independent authors and included all levels of evidence. This included all English language literature, pertaining specifically to etiopathology of knee OCD with exclusions for review articles and expert opinion. Of 965 identified records, 154 full-text articles were assessed for eligibility and 86 studies met the inclusion criteria. According to these studies, the etiology of OCD can be of a biological or mechanical origin: 40 articles proposed a biological hypothesis, including genetic causes (27), ossification center deficit (12), and endocrine disorders (9); conversely, 52 articles supported a mechanical hypothesis, including injury/overuse (18), tibial spine impingement (5), discoid meniscus (16), and biomechanical alterations (20) as the cause of the onset of OCD. The pathogenic processes were investigated by 36 of these articles, with a focus on ...Continue Reading

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Citations

Aug 19, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Luca AndrioloGiuseppe Filardo
Jun 14, 2019·EFORT Open Reviews·Javier Masquijo, Alpesh Kothari
Dec 14, 2018·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Giuseppe FilardoDennis C Crawford
Nov 25, 2020·Journal of Pediatric Orthopedics·J Javier MasquijoMiguel Carabajal
Jan 29, 2021·BMJ Case Reports·Elizabeth A EichmanM Tyrrell Burrus
Jun 25, 2021·Anatomy & Cell Biology·Hyejin LeeDong Hoon Shin

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