Osteochondroma in long-term survivors of high-risk neuroblastoma

Cancer
B H KushnerNai-Kong V Cheung

Abstract

Osteochondromas are benign bony protrusions that can be spontaneous or associated with radiotherapy (RT). Current treatment of high-risk neuroblastoma includes dose-intensive chemotherapy, local RT, an anti-GD2 monoclonal antibody (MoAb), and isotretinoin. Late effects are emerging. The authors examined osteochondromas in 362 patients who were aged <10 years when diagnosed with neuroblastoma, had received a MoAb plus isotretinoin since 2000, and had survived >24 months from the time of the first dose of the MoAb. The incidence rate of osteochondroma was determined using the competing risks approach, in which the primary event was osteochondroma calculated from the date of neuroblastoma diagnosis and the competing event was death without osteochondroma. A total of 21 osteochondroma cases were found among 14 patients who were aged 5.7 to 15.3 years (median, 10.4 years) and 3.1 to 11.2 years (median, 8.2 years) from the time of neuroblastoma diagnosis. The cumulative incidence rate was 0.6% at 5 years and 4.9% at 10 years from the neuroblastoma diagnosis. Nine osteochondromas were revealed incidentally during assessments of neuroblastoma disease status or bone age. Thirteen osteochondromas were detected outside RT portals and had ...Continue Reading

References

Mar 1, 1982·Radiology·H I Libshitz, M A Cohen
May 1, 1983·International Journal of Radiation Oncology, Biology, Physics·N JaffeM P Sullivan
Feb 1, 1982·International Journal of Radiation Oncology, Biology, Physics·H D ThamesG H Fletcher
Feb 1, 1994·Spine·A K CreeG K Chapman
May 26, 1998·Journal of Pediatric Orthopedics·G D HarperA D Leiper
Sep 19, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·M D MurpheyF H Gannon
Jun 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B H KushnerN K Cheung
Jan 19, 2002·Clinical Radiology·K C Y LeeV N Cassar-Pullicino
Apr 18, 2002·International Journal of Radiation Oncology, Biology, Physics·Arnold C PaulinoJohn M Buatti
Apr 18, 2002·European Radiology·Luis GorospeFernando López-Barea
Apr 30, 2002·Bone Marrow Transplantation·P BordigoniF Plenat
Jan 24, 2003·The New England Journal of Medicine·Karl MichaëlssonHåkan Melhus
Apr 16, 2003·International Journal of Radiation Oncology, Biology, Physics·Daphne A Haas-KoganKatherine K Matthay
Jun 5, 2003·Clinical Orthopaedics and Related Research·Adel Refaat AhmedFranklin H Sim
Nov 1, 1952·Radiology·E B D NEUHAUSERJ COHEN
Jan 31, 2004·Pediatric Blood & Cancer·Jonathan TaitzMarcus R Vowels
Feb 17, 2005·Pediatric Blood & Cancer·Caroline LaverdièreCharles A Sklar
Apr 5, 2005·Pediatric Hematology and Oncology·Arnold C Paulino, B Zach Fowler
Jan 24, 2006·International Journal of Radiation Oncology, Biology, Physics·Isabelle FlandinChristian Carrie
Feb 17, 2006·Journal of Pediatric Surgery·Mauricio A EscobarFrederick J Rescorla
Mar 3, 2007·Pediatrics·Joseph D Dickerman
Feb 15, 2008·Orphanet Journal of Rare Diseases·Judith V M G Bovée
Jul 16, 2008·Pediatric Blood & Cancer·Wendy L HobbieJill P Ginsberg
Oct 8, 2008·Pediatric Blood & Cancer·Aurélien MarabelleJustyna Kanold
Jan 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Brian H KushnerNai-Kong V Cheung
Jan 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine K MatthayJudith G Villablanca
Feb 20, 2009·Orthopedics·Andreas F MavrogenisPanayotis N Soucacos
Aug 4, 2009·Journal of the National Cancer Institute·Caroline LaverdièreCharles A Sklar
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Maura FaraciUNKNOWN AIEOP-HSCT Group
Jun 19, 2010·The New England Journal of Medicine·John M Maris
Oct 1, 2010·The New England Journal of Medicine·Alice L YuUNKNOWN Children's Oncology Group
Feb 15, 2011·Pediatric Blood & Cancer·Thomas PerweinChristian Urban
Jan 17, 2012·Journal of Pediatric Hematology/oncology·Yoji ShidoYoshihiro Nishida
Aug 8, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nai-Kong V CheungShakeel Modak
Jan 3, 2013·Pediatric Blood & Cancer·Lucas MorenoUNKNOWN Children's Cancer and Leukaemia Group (CCLG) (formerly UKCCSG)

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