Osteoclast differentiation during experimental tooth movement by a short-term force application: an immunohistochemical study in rats

Acta Odontologica Scandinavica
Rui XieJaap C Maltha

Abstract

The origin of osteoclasts responsible for bone resorption during orthodontic tooth movement is not yet clear. Their precursors may reside within the periodontal ligament (PDL) or could be recruited from the circulation or the bone marrow. The aim of this study was to investigate the spatial and sequential distribution of osteoclast precursors during experimental tooth movement by using three differentiation markers: receptor for macrophage colony stimulating factor (c-Fms), receptor activator of nuclear factor-kappaB (RANK), and calcitonin receptor (CTR). Six-week-old Wistar rats were used. Elastic bands were inserted between the upper 1st and 2nd molars for 1, 2, 3, and 6 days. Immunohistochemical staining for c-Fms, RANK, or CTR was performed on parasagittal sections and positive cells were counted. Before force application, many c-Fms+ and a few RANK+ precursors were present in the bone marrow. No c-Fms+ osteoclast precursors were observed in the PDL. After force application, the number of RANK+ but not c-Fms+ precursors increased rapidly in the PDL. In bone marrow, the number of c-Fms+ and RANK+ precursors also increased rapidly, as did multinuclear c-Fms+, RANK+, and CTR+ cells. Subsequently, the number of c-Fms+, RANK+, a...Continue Reading

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Citations

Dec 15, 2011·Journal of Periodontology·Faika SaidBlandine Ruhin-Poncet
Jan 7, 2011·The Angle Orthodontist·Patricia J BrooksSiew-Ging Gong
Dec 18, 2015·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Alja PlutMartina Drevenšek
Jul 21, 2011·Orthodontics & Craniofacial Research·A Iglesias-LinaresE Solano-Reina
Jul 31, 2009·Journal of Dental Research·V Krishnan, Z Davidovitch
Jul 2, 2015·Journal of Dental Research·M ZengY Zhou
Dec 14, 2017·International Journal of Oral Science·Nam C-N HuynhRuchanee S Ampornaramveth

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