PMID: 1864595Jun 1, 1991Paper

Osteoclast-like giant cell tumor of the pancreas: immunophenotypic similarity to giant cell tumor of bone

Human Pathology
R D GoldbergA G Montag

Abstract

An immunophenotype was performed on an osteoclast-like giant cell tumor of the pancreas using a panel of antibodies to epithelial and leukocyte antigens. Several antibodies to cytokeratin and carcinoembryonic antigen were negative in the tumor. Osteoclast-like cells were positive for CD4, CD13, CD45, CD68, CD71, and vimentin, but negative for lysozyme and HLA-DR. Mononuclear tumor cells were positive for CD4, CD11c, CD13, CD14, CD45, CD68, CD71, HLA-DR, and vimentin, but negative for lysozyme. The phenotype is similar to that previously described for giant cell tumor of bone. The osteoclast-like cell phenotype is also similar to that reported for normal osteoclasts. The findings support a nonepithelial origin for osteoclast-like giant cell tumor of the pancreas, and suggest a derivation similar to giant cell tumor of bone.

References

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Citations

May 1, 1996·The Australian and New Zealand Journal of Surgery·P M MercerJ J Murphy
Jan 18, 2013·Journal of Cytology·Shanthakumari SivanandhamK Rajeshwari Muthusamy
Jul 29, 2006·Pathology International·Shih-Che ShenTse-Ching Chen
Apr 21, 2010·Pathology International·Hiroe ItamiToshiko Sakuma
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Nov 9, 2011·Journal of the Korean Surgical Society·Young Hoe HurChol Kyoon Cho
Nov 29, 2007·The American Journal of Surgical Pathology·Frank BergmannPeter Schirmacher
Mar 13, 2008·Diagnostic Cytopathology·Lester J Layfield, Joel Bentz
May 22, 2008·Pathology Oncology Research : POR·George Burkadze, Gulisa Turashvili
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Dec 19, 2013·Oncology Letters·Joshua Robert KaneAnjana V Yeldandi
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Mar 6, 2008·Archives of Pathology & Laboratory Medicine·Stephen A GellerRanda Alsabeh
Aug 1, 1995·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·S BergmanK B Lewandrowski
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