Osteoclast stimulation by positive middle-ear air pressure

Archives of Otolaryngology--head & Neck Surgery
D E Wolfman, R A Chole

Abstract

The mechanism of pathologic bone resorption associated with cholesteatoma is controversial. It is now evident that transmitted pressure is a significant factor in the activation of osteoclasts. Previous studies on the effect of pressure have been confounded by the possible foreign body effect of materials placed into the middle ear to induce the pressure. Positive air pressures were maintained in the middle ear of Mongolian gerbils via implanted Silastic catheters. Histologic evaluation of the ventral bulla wall was performed after pressure had been applied for two weeks. A significant increase in the number density, area density, and size of osteoclasts present in the pressurized bullae was noted at pressures of 4, 6, 10, and 20 mm Hg, but not at 2 mm Hg. We conclude that minute increases in pressure, in the absence of foreign objects, stimulate osteoclastic bone resorption in the middle ear of the gerbil.

Citations

Feb 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R A CholeS P Tinling
Apr 1, 1991·Calcified Tissue International·M C Jungkeit, R A Chole
Oct 23, 1997·The Laryngoscope·M JohnsonD L Kreutzer
Oct 15, 2013·The Laryngoscope·Khac-Hung NguyenYoshiaki Doi
Jul 22, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Michelle Christine NielsenMads Sølvsten Sørensen
Jul 22, 2016·Clinical and Experimental Otorhinolaryngology·Mahmood A HamedKenji Suzuki
Dec 17, 2016·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Shumin XieWei Liu
Aug 1, 1993·The Annals of Otology, Rhinology, and Laryngology·R A Chole
Dec 1, 1999·The Annals of Otology, Rhinology, and Laryngology·B E Sherman, R A Chole
Sep 1, 1990·The Annals of Otology, Rhinology, and Laryngology·K Adachi, R A Chole
Nov 1, 1988·The Annals of Otology, Rhinology, and Laryngology·R A Chole
Jul 13, 2000·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·B E Sherman, R A Chole
Jun 19, 2001·The Laryngoscope·J B Vander MeerT L Smith
Jan 23, 1999·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·M J Choo, R A Chole

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