Osteoclast stimulatory transmembrane protein and dendritic cell–specific transmembrane protein cooperatively modulate cell–cell fusion to form osteoclasts and foreign body giant cells

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Hiroya MiyamotoTakeshi Miyamoto

Abstract

Cell–cell fusion is a dynamic phenomenon promoting cytoskeletal reorganization and phenotypic changes. To characterize factors essential for fusion of macrophage lineage cells, we identified the multitransmembrane protein, osteoclast stimulatory transmembrane protein (OC-STAMP), and analyzed its function. OC-STAMP–deficient mice exhibited a complete lack of cell–cell fusion of osteoclasts and foreign body giant cells (FBGCs), both of which are macrophage-lineage multinuclear cells, although expression of dendritic cell specific transmembrane protein (DC-STAMP), which is also essential for osteoclast/FBGC fusion, was normal. Crossing OC-STAMP–overexpressing transgenic mice with OC-STAMP–deficient mice restored inhibited osteoclast and FBGC cell–cell fusion seen in OC-STAMP–deficient mice. Thus, fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP.

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Citations

Apr 30, 2013·Journal of Bone and Mineral Metabolism·Young Sun HwangWon-Yoon Chung
Aug 7, 2012·The Journal of Biological Chemistry·Hiroya MiyamotoTakeshi Miyamoto
Mar 19, 2014·PloS One·Mercedes F RiveraLakshmyya Kesavalu
Jan 31, 2013·World Journal of Orthopedics·Lianping XingBrendan F Boyce
Mar 8, 2014·BoneKEy Reports·Naoyuki TakahashiTatsuo Suda
Aug 8, 2014·Arthritis Research & Therapy·Stéphanie PutPatrick Matthys
Jun 4, 2014·Journal of Cellular Physiology·Rabia IslamHyun-Mo Ryoo
Mar 11, 2015·Clinical Oral Implants Research·Jordi Caballé-SerranoReinhard Gruber
Aug 29, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Virginia StiffelK-H William Lau
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Mar 22, 2015·Biochemical and Biophysical Research Communications·Hiroyasu KiyomiyaTatsuji Nishihara
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