Osteoclastic giant cell tumor of the pancreas

International Journal of Surgery Case Reports
Wudneh M TemesgenSharmila Dissanaike

Abstract

Pancreatic giant cell tumors are rare, with an incidence of less than 1% of all pancreatic tumors. Osteoclastic giant cell tumor (OGCT) of the pancreas is one of the three types of PGCT, which are now classified as undifferentiated carcinoma with osteoclast-like giant cells. The patient is a 57 year old woman who presented with a 3 week history of epigastric pain and a palpable abdominal mass. Imaging studies revealed an 18cm×15cm soft tissue mass with cystic components which involved the pancreas, stomach and spleen. Exploratory laparotomy with distal pancreatectomy, partial gastrectomy and splenectomy was performed. Histology revealed undifferentiated pancreatic carcinoma with osteoclast-like giant cells with production of osteoid and glandular elements. OGCT of the pancreas resembles benign-appearing giant cell tumors of bone, and contain osteoclastic-like multinucleated cells and mononuclear cells. OGCTs display a less aggressive course with slow metastasis and lymph node spread compared to pancreatic adenocarcinoma. Due to the rarity of the cancer, there is a lack of prospective studies on treatment options. Surgical en-bloc resection is currently considered first line treatment. The role of adjuvant therapy with radiother...Continue Reading

References

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Citations

Jan 15, 2015·Case Reports in Pathology·Lucía Alemán-MezaAbelardo Loya-Solis
Apr 11, 2019·Tumori·Oronzo BrunettiNicola Silvestris
Aug 1, 2017·International Cancer Conference Journal·Tomohiro YazawaKen Shirabe
Dec 19, 2019·Frontiers in Cell and Developmental Biology·Xinlong WangBei Sun
Dec 4, 2020·International Journal of Molecular Sciences·Chiara BazzichettoMichele Milella
Jan 16, 2021·Journal of Gastrointestinal Cancer·Ayoub KharkhachTijani El Harroudi

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Methods Mentioned

BETA
hysterectomy
surgical resection

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