Osteoclastogenesis and osteoclastic resorption of tricalcium phosphate: effect of strontium and magnesium doping.

Journal of Biomedical Materials Research. Part a
Mangal Roy, Susmita Bose

Abstract

Bone substitute materials are required to support the remodeling process, which consists of osteoclastic resorption and osteoblastic synthesis. Osteoclasts, the bone-resorbing cells, generate from differentiation of hemopoietic mononuclear cells. In the present study, we have evaluated the effects of 1.0 wt % strontium (Sr) and 1.0 wt % magnesium (Mg) doping in beta-tricalcium phosphate (β-TCP) on the differentiation of mononuclear cells into osteoclast-like cells and its resorptive activity. In vitro osteoclast-like cell formation, adhesion, and resorption were studied using osteoclast precursor RAW 264.7 cell, supplemented with receptor activator of nuclear factor κβ ligand (RANKL). Osteoclast-like cell formation was noticed on pure and Sr-doped β-TCP samples at day 8, which was absent on Mg-doped β-TCP samples indicating decrease in initial osteoclast differentiation due to Mg doping. After 21 days of culture, osteoclast-like cell formation was evident on all samples with osteoclastic markers such as actin ring, multiple nuclei, and presence of vitronectin receptor α(v)β(3) integrin. After osteoclast differentiation, all substrates showed osteoclast-like cell-mediated degradation, however, significantly restricted for Mg-dop...Continue Reading

References

Apr 11, 1997·Science·J SaloH K Väänänen
Sep 1, 2000·Science·S L Teitelbaum
Sep 11, 2002·Angewandte Chemie·Sergey V Dorozhkin, Matthias Epple
May 16, 2003·Nature·William J BoyleDavid L Lacey
Mar 30, 2004·Biomaterials·Arndt F SchillingMichael Amling
Jun 2, 2006·Journal of Biomedical Materials Research. Part a·C M BotelhoW Bonfield
Jul 10, 2007·Journal of Biomedical Materials Research. Part a·Yasutaka YamadaRacquel Z LeGeros
Aug 29, 2007·Acta Biomaterialia·R DetschG Ziegler
Feb 14, 2008·Journal of Materials Science. Materials in Medicine·Weichang XueSusmita Bose
Jul 23, 2008·Acta Biomaterialia·Xia LiR Z LeGeros
Oct 16, 2009·Journal of the American College of Nutrition·Robert K RudeHelen E Gruber

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Citations

Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Neusa M F CostaJosé M Granjeiro
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Partha SahaPrashant N Kumta
Dec 15, 2012·Journal of Biomedical Materials Research. Part a·Debora H YassudaGlória de A Soares
Jan 31, 2014·Journal of Tissue Engineering and Regenerative Medicine·Rainer Detsch, Aldo R Boccaccini
Aug 16, 2013·Journal of Biomedical Materials Research. Part a·Gary A FieldingSusmita Bose
May 24, 2016·Biochimica Et Biophysica Acta·Victoria M Wu, Vuk Uskoković
Nov 4, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sahar VahabzadehSusmita Bose
Mar 3, 2018·Journal of Functional Biomaterials·Chris SteffiWilson Wang
Apr 23, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ana Carolina Cestari BighettiRumio Taga
Jul 17, 2018·Journal of Cell Communication and Signaling·Tianhao SunSonglin Peng
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcela Martín-Del-CampoLuis Rojo
Nov 27, 2020·International Journal of Nanomedicine·Haiyan WangJing Guo
Apr 4, 2021·Materials·Andreea-Mariana Negrescu, Anisoara Cimpean
Jan 12, 2015·ACS Biomaterials Science & Engineering·Nicole OstrowskiPrashant N Kumta
Jul 11, 2016·ACS Biomaterials Science & Engineering·Nicole OstrowskiPrashant N Kumta
Oct 14, 2019·ACS Biomaterials Science & Engineering·Kaushik SarkarMangal Roy

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