Abstract
Bone substitute materials are required to support the remodeling process, which consists of osteoclastic resorption and osteoblastic synthesis. Osteoclasts, the bone-resorbing cells, generate from differentiation of hemopoietic mononuclear cells. In the present study, we have evaluated the effects of 1.0 wt % strontium (Sr) and 1.0 wt % magnesium (Mg) doping in beta-tricalcium phosphate (β-TCP) on the differentiation of mononuclear cells into osteoclast-like cells and its resorptive activity. In vitro osteoclast-like cell formation, adhesion, and resorption were studied using osteoclast precursor RAW 264.7 cell, supplemented with receptor activator of nuclear factor κβ ligand (RANKL). Osteoclast-like cell formation was noticed on pure and Sr-doped β-TCP samples at day 8, which was absent on Mg-doped β-TCP samples indicating decrease in initial osteoclast differentiation due to Mg doping. After 21 days of culture, osteoclast-like cell formation was evident on all samples with osteoclastic markers such as actin ring, multiple nuclei, and presence of vitronectin receptor α(v)β(3) integrin. After osteoclast differentiation, all substrates showed osteoclast-like cell-mediated degradation, however, significantly restricted for Mg-dop...Continue Reading
References
Apr 11, 1997·Science·J SaloH K Väänänen
Sep 1, 2000·Science·S L Teitelbaum
Sep 11, 2002·Angewandte Chemie·Sergey V Dorozhkin, Matthias Epple
May 16, 2003·Nature·William J BoyleDavid L Lacey
Mar 30, 2004·Biomaterials·Arndt F SchillingMichael Amling
Dec 29, 2004·Biomaterials·R EnderleP Greil
May 25, 2006·Biomaterials·Zhidao XiaJake E Barralet
Jun 2, 2006·Journal of Biomedical Materials Research. Part a·C M BotelhoW Bonfield
Feb 24, 2007·Biomaterials·Takatoshi OkudaTohru Ikeda
Jul 10, 2007·Journal of Biomedical Materials Research. Part a·Yasutaka YamadaRacquel Z LeGeros
Aug 29, 2007·Acta Biomaterialia·R DetschG Ziegler
Feb 14, 2008·Journal of Materials Science. Materials in Medicine·Weichang XueSusmita Bose
Jun 17, 2008·Acta Biomaterialia·C CapucciniA Bigi
Jul 23, 2008·Acta Biomaterialia·Xia LiR Z LeGeros
Nov 11, 2008·Biomaterials·Somying PatntirapongPeter V Hauschka
Aug 15, 2009·Acta Biomaterialia·S KannanJ M F Ferreira
Oct 16, 2009·Journal of the American College of Nutrition·Robert K RudeHelen E Gruber
Dec 29, 2009·Acta Biomaterialia·C JanningF Witte
Feb 4, 2010·Biomaterials·Liang YangPamela Habibovic
Mar 9, 2010·Acta Biomaterialia·R DetschM Epple
May 25, 2010·Acta Biomaterialia·Shashwat S BanerjeeSusmita Bose
Feb 5, 2011·Biomaterials·Alexander HoppeAldo R Boccaccini
Mar 23, 2011·Bone·Susmita BoseAmit Bandyopadhyay
Citations
Aug 15, 2014·PloS One·Yufeng ZhangRichard J Miron
Feb 4, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Neusa M F CostaJosé M Granjeiro
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Partha SahaPrashant N Kumta
Dec 15, 2012·Journal of Biomedical Materials Research. Part a·Debora H YassudaGlória de A Soares
Jan 31, 2014·Journal of Tissue Engineering and Regenerative Medicine·Rainer Detsch, Aldo R Boccaccini
Mar 13, 2014·Journal of Tissue Engineering and Regenerative Medicine·Timothy E L DouglasPeter Dubruel
Aug 16, 2013·Journal of Biomedical Materials Research. Part a·Gary A FieldingSusmita Bose
May 24, 2016·Biochimica Et Biophysica Acta·Victoria M Wu, Vuk Uskoković
Nov 4, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Sahar VahabzadehSusmita Bose
Jul 5, 2017·ACS Applied Materials & Interfaces·Lin WengJingwei Xie
Mar 3, 2018·Journal of Functional Biomaterials·Chris SteffiWilson Wang
May 8, 2019·Journal of Functional Biomaterials·Elisa BoaniniAdriana Bigi
Apr 23, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Ana Carolina Cestari BighettiRumio Taga
Apr 6, 2019·Biomedical Materials·Ajay SuryavanshiRohit Srivastava
Jul 17, 2018·Journal of Cell Communication and Signaling·Tianhao SunSonglin Peng
May 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marcela Martín-Del-CampoLuis Rojo
Nov 23, 2015·Materials·Zeeshan SheikhMichael Glogauer
Nov 27, 2020·International Journal of Nanomedicine·Haiyan WangJing Guo
Apr 4, 2021·Materials·Andreea-Mariana Negrescu, Anisoara Cimpean
Mar 11, 2019·ACS Biomaterials Science & Engineering·Dongxu KeSusmita Bose
Jan 12, 2015·ACS Biomaterials Science & Engineering·Nicole OstrowskiPrashant N Kumta
Jul 11, 2016·ACS Biomaterials Science & Engineering·Nicole OstrowskiPrashant N Kumta
Nov 13, 2020·ACS Applied Materials & Interfaces·Ashley A Vu, Susmita Bose
Oct 14, 2019·ACS Biomaterials Science & Engineering·Kaushik SarkarMangal Roy
Nov 11, 2019·ACS Biomaterials Science & Engineering·Simone SprioAnna Tampieri