Osteoconductive properties of upside-down bilayer collagen membranes in rat calvarial defects.

International Journal of Implant Dentistry
Balazs FeherReinhard Gruber

Abstract

Bilayer collagen membranes are routinely used in guided bone/tissue regeneration to serve as osteoconductive scaffolds and prevent the invasion of soft tissues. It is recommended to place the membranes with their dense layer towards the soft tissue and their porous layer towards the bony defect area. However, evidence supporting this recommendation is lacking. This study aimed to determine whether the alignment of bilayer collagen membranes has an effect on bone regeneration. In two groups of ten male Sprague-Dawley rats each, a 5-mm calvarial defect was created. Thereafter, the defect was randomly covered with a bilayer, resorbable, pure type I and III collagen membrane placed either regularly or upside-down (i.e., dense layer towards bone defect). After 4 weeks of healing, micro-computed tomography (μCT), histology, and histomorphometry of the inner cylindrical region of interest (4.5 mm in diameter) were performed to assess new bone formation and the consolidation of the collagen membrane in the defect area. Quantitative μCT showed similar bone volume (median 8.0 mm3, interquartile range 7.0-10.0 vs. 6.2 mm3, 4.3-9.4, p = 0.06) and trabecular thickness (0.21 mm, 0.19-0.23 vs. 0.18 mm, 0.17-0.20, p = 0.03) between upside-down...Continue Reading

References

May 1, 1988·Plastic and Reconstructive Surgery·C DahlinS Nyman
Feb 1, 1995·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·C H HämmerleA J Olah
Apr 6, 2001·Journal of Periodontology·P Bunyaratavej, H L Wang
Sep 3, 2003·Periodontology 2000·Christoph H F Hämmerle, Ronald E Jung
Jul 30, 2010·Clinical Oral Implants Research·Maria Retzepi, N Donos
Mar 13, 2012·Journal of Biomedical Materials Research. Part a·Tae Ho KimJin Ho Lee
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Sep 26, 2012·Journal of Periodontology·Ahmed Y Gamal, Vincent J Iacono
Apr 20, 2013·Journal of Structural Biology·Fabio NudelmanEli D Sone
Aug 16, 2014·Periodontology 2000·Goran I Benic, Christoph H F Hämmerle
Aug 4, 2016·Development·Kishor K Sivaraj, Ralf H Adams
Aug 24, 2017·European Journal of Oral Sciences·Ibrahim ElgaliPeter Thomsen
Feb 28, 2018·Periodontology 2000·Ronald E JungDaniel S Thoma
Nov 23, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Behnoush KhorsandAliasger K Salem
Nov 14, 2019·Materials·Jordi Caballé-SerranoDieter D Bosshardt
Jul 2, 2020·Journal of Biomedical Materials Research. Part a·Franz-Josef StraussReinhard Gruber

❮ Previous
Next ❯

Citations

Jul 3, 2021·Biomedicines·Karol Alí Apaza AlccayhuamanReinhard Gruber

❮ Previous
Next ❯

Software Mentioned

ImageJ
ARRIVE

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.