Osteocyte morphology and orientation in relation to strain in the jaw bone

International Journal of Oral Science
Vivian WuJenneke Klein-Nulend

Abstract

Bone mass is important for dental implant success and is regulated by mechanoresponsive osteocytes. We aimed to investigate the relationship between the levels and orientation of tensile strain and morphology and orientation of osteocytes at different dental implant positions in the maxillary bone. Bone biopsies were retrieved from eight patients who underwent maxillary sinus-floor elevation with β-tricalcium phosphate prior to implant placement. Gap versus free-ending locations were compared using 1) a three-dimensional finite-element model of the maxilla to predict the tensile strain magnitude and direction and 2) histology and histomorphometric analyses. The finite-element model predicted larger, differently directed tensile strains in the gap versus free-ending locations. The mean percentage of mineralised residual native-tissue volume, osteocyte number (mean ± standard deviations: 97 ± 40/region-of-interest), and osteocyte shape (~90% elongated, ~10% round) were similar for both locations. However, the osteocyte surface area was 1.5-times larger in the gap than in the free-ending locations, and the elongated osteocytes in these locations were more cranially caudally oriented. In conclusion, significant differences in the o...Continue Reading

References

Jan 1, 1991·Archives of Oral Biology·T M van Eijden
May 25, 1999·Periodontology 2000·R K Schenk, D Buser
Jun 19, 2001·The Journal of Prosthetic Dentistry·J P GengG R Liu
Jul 10, 2004·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Christina LindhArne Petersson
Nov 10, 2004·Clinical Oral Implants Research·Ilara R ZerboElizabeth H Burger
Dec 31, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·James G McGarryPatrick J Prendergast
May 5, 2006·Clinical Oral Implants Research·Natalia Lioubavina-HackThorkild Karring
May 23, 2007·Clinical Oral Implants Research·Nicholas A DrageIgnac Fogelman
Apr 12, 2008·Journal of Biomechanics·Rommel G BacabacTheo H Smit
Feb 2, 2010·Journal of Oral Rehabilitation·L-J FuhJ-T Hsu
Oct 30, 2010·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·B Hohlweg-MajertD Schulze
Nov 18, 2010·Journal of Structural Biology·Michael KerschnitzkiPeter Fratzl
Oct 23, 2012·Bone·Jenneke Klein-NulendSheldon Weinbaum
Feb 11, 2015·Current Osteoporosis Reports·René F M van OersRommel G Bacabac

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Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

SPSS
ImageJ
Leica QWin ©
Abaqus
/ CAE

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