PMID: 6981344Sep 1, 1982Paper

Osteogenesis imperfecta tarda in a child with hyper-IgE syndrome

American Journal of Diseases of Children
E P BrestelJ S Dorn

Abstract

A patient had recurrent pyogenic infections, chronic mucocutaneous candidiasis, and repeated long-bone fractures. Her disorder was diagnosed as hyper-IgE syndrome on the basis of clinical data, elevated levels of serum IgE, increased levels of IgE specific for Staphylococcus aureus, and impaired T-lymphocyte function. Roentgenograms confirmed the diagnosis of osteogenesis imperfecta tarda. The estimated likelihood of both conditions occurring in the same person is approximately one in 10 billion. The coincident finding of bone dysplasia in a patient with impaired T-lymphocyte function suggests a common mechanism for birth defects.

Citations

Nov 1, 1985·European Journal of Pediatrics·P H HögerW H Hitzig
Nov 17, 2011·Orphanet Journal of Rare Diseases·Aleksandra Szczawinska-PoplonykKarolina Gerreth
Sep 12, 2000·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M D Erlewyn-Lajeunesse
Mar 4, 1999·The New England Journal of Medicine·B GrimbacherJ M Puck
Jun 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Prem Swaroop YadavYingzi Yang

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