PMID: 7021562Jan 1, 1981Paper

Osteogenesis in bone grafts after short-term storage and topical antibiotic treatment. An experimental study in rats

The Journal of Bone and Joint Surgery. British Volume
J C Gray, M W Elves

Abstract

It has been shown in experimental animals that the living cells in a bone autograft can make an important contribution to osteogenesis. However, some common clinical techniques, such as the topical use of antibiotic powders on grafts or on the graft bed, are likely to damage or kill the cells. In this experimental study in rats, bone isografts dusted with chloramphenicol or methicillin powder or with Polybactrin spray before subcutaneous implantation produced little or no new bone over a period of two weeks whereas untreated, control grafts showed abundant osteogenesis, as did grafts pretreated with solutions of antibiotics. The effect of short-term storage of the grafts for 3 to 24 hours in air, saline or culture medium before implantation was also examined. Grafts stored in culture medium generally did as well as, or better than, fresh control grafts whereas immersion in saline inhibited osteogenesis. The importance of these results for clinical bone grafting is discussed.

Citations

May 8, 2007·Clinical Orthopaedics and Related Research·Martin ButtaroFrancisco Piccaluga
Oct 17, 2019·Journal of Tissue Engineering and Regenerative Medicine·Qiang SunJill A Helms
Mar 1, 1986·Head & Neck Surgery·D S Soutar, W P Widdowson
Apr 5, 2008·Archives of Orthopaedic and Trauma Surgery·Uwe MausChristopher Niedhart
Oct 1, 2005·Acta Orthopaedica·Eivind WitsøKåre Bergh
Mar 4, 2011·The Journal of Bone and Joint Surgery. American Volume·Jennifer BauerAllison Gilmore
Nov 1, 1996·The Journal of Small Animal Practice·J A Culvenor, R J Parker
Jan 29, 2013·International Orthopaedics·Hans-Jürgen KockWerner Fabry
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