Osteogenic and angiogenic potentials of the cell-laden hydrogel/mussel-inspired calcium silicate complex hierarchical porous scaffold fabricated by 3D bioprinting

Materials Science & Engineering. C, Materials for Biological Applications
Yi-Wen ChenMing-You Shie

Abstract

3D printing has been popularly used in the bone tissue engineering, as many of the biomaterials for this field of study can be prepared for and produced from this additive manufacturing technique. In this study, we strategized a solvent-free processing to fabricate the polydopamine-modified calcium silicate (PDACS)/poly-caprolactone (PCL) scaffold with Wharton's jelly mesenchymal stem cells (WJMSCs) incorporated with human umbilical vein endothelial cells (HUVEC)-laden hydrogel. The PDACS/PCL/hydrogel 3D scaffold yielded a Young's modulus of the 3D scaffolds as high as 75 MPa. In addition, the vascular morphogenesis and cellular behaviors regulated by our hybrid scaffolds were also intricately evaluated. Furthermore, the HUVEC in the bioink exhibited higher levels of angiogenic biomarkers and showed potential for the formation of complex vascular networks. Higher levels of bone formation proteins were also observed in our composites. Such a hybrid of synthetic materials with cell constituents not only enhances osteogenesis but also stimulates vessel network development in angiogenesis, presenting the fact that 3D printing can be further applied in improving bone tissue regeneration in numerous aspects. We believe that this meth...Continue Reading

Citations

Jul 5, 2019·Chemical Society Reviews·Laurine ValotGilles Subra
Jul 18, 2019·Critical Reviews in Food Science and Nutrition·Chang HeZhongxiang Fang
Jun 22, 2019·Journal of Materials Science. Materials in Medicine·Cheng-Hsin ChengMing-You Shie
Feb 12, 2020·Advanced Materials·Riccardo LevatoJos Malda
May 21, 2020·Materials·Fei XingUlrike Ritz
Nov 16, 2019·Polymers·Ming-You ShieYi-Wen Chen
Dec 14, 2018·Frontiers in Bioengineering and Biotechnology·Gunpreet OberoiHermann Agis
Nov 30, 2019·Stem Cells International·Gabriele StortiValerio Cervelli
Oct 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·S SwethaN Selvamurugan
Sep 2, 2020·Chemical Reviews·Ryan W BarrsYing Mei
Jun 1, 2021·Frontiers in Bioengineering and Biotechnology·Earnest P ChenJohn P Geibel
Jul 17, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Chun-Liang YehChun-Pin Lin
Dec 18, 2021·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Eduardo Henrique BackesLuiz Antonio Pessan

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