Osteogenic effect of high-frequency acceleration on alveolar bone.

Journal of Dental Research
M AlikhaniC C Teixeira

Abstract

Mechanical stimulation contributes to the health of alveolar bone, but no therapy using the osteogenic effects of these stimuli to increase alveolar bone formation has been developed. We propose that the application of high-frequency acceleration to teeth in the absence of significant loading is osteogenic. Sprague-Dawley rats were divided among control, sham, and experimental groups. The experimental group underwent localized accelerations at different frequencies for 5 min/day on the occlusal surface of the maxillary right first molar at a very low magnitude of loading (4 µε). Sham rats received a similar load in the absence of acceleration or frequency. The alveolar bone of the maxilla was evaluated by microcomputed tomography (µCT), histology, fluorescence microscopy, scanning electron microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR imaging), and RT-PCR for osteogenic genes. Results demonstrate that application of high-frequency acceleration significantly increased alveolar bone formation. These effects were not restricted to the area of application, and loading could be replaced by frequency and acceleration. These studies propose a simple mechanical therapy that may play a significant role in alveolar bone...Continue Reading

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Citations

Jun 17, 2014·PloS One·Jaime JacquesJuliane Isaac
Mar 7, 2015·European Journal of Orthodontics·Sumit YadavRavindra Nanda
Sep 1, 2015·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Sumit YadavRavindra Nanda
Jun 18, 2017·International Journal of Oral Science·Marissa ChatterjeeKatleen Vandamme
Dec 17, 2015·Journal of Dental Research·M AlikhaniC C Teixeira
Jan 30, 2019·PloS One·Mani AlikhaniCristina C Teixeira
Sep 10, 2019·Journal of Orthodontic Science·Thomas ShipleyTarek El-Bialy
Jun 24, 2017·Orthodontics & Craniofacial Research·F UribeT Chandhoke
Aug 30, 2019·Journal of Family Medicine and Primary Care·Sridhar KannanNeeraj Saini
Nov 7, 2018·Dose-response : a Publication of International Hormesis Society·Stefan Judex, Suphannee Pongkitwitoon
May 10, 2018·Scientific Reports·Peter J WatsonFlora Gröning
May 8, 2018·PloS One·Mani AlikhaniCristina C Teixeira
May 1, 2021·Scanning·Yanxin QiHeng Bo Jiang
Dec 3, 2021·International Journal of Radiation Biology·Sridhar Reddy PadalaArja M Kullaa

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Methods Mentioned

BETA
fluorescence microscopy
Fluorescence
light

Software Mentioned

Catman
NIS
SPIDER
ISYS Chemical Imaging
Elements

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