Osteogenic Evaluation of Goose-beak Bones According to Processing Temperature

In Vivo
Jong Min Kim, Seok Hwa Choi

Abstract

As an alternative material to autogenous bone, goose-beak bone particles (GBP) have been attracting great attention as a bone substitute due to their biological properties. This study was performed to assess bone generation using GBP in calvarial defects in a rat model. The study focus was the osteogenic potential of goose-beak bone at different processing temperatures. There were three experimental groups: Control group (critical defect only), low-temperature (LT) group (filled with GBP heat-treated for 20 h at 400°C), and high-temperature (HT) group (filled with GBP heat-treated for 3 h at 1,200°C). The Ca/P atomic ratio of the goose-beak bone was 1.63, and the bones had a bony structure with open pores and interconnected rod-like struts. Micro-computed tomographic analysis revealed the quantity of new bone formation of the HT group was higher than that of the LT group. At 12 weeks after GBP insertion, new bone formation was significantly higher (p<0.05) in the HT group, and there were more new osteocytes in the lacuna in the HT group than in the LT group. Thus, GBP treated at a high temperature formed more new bone than that treated at a low temperature. It can be concluded that HT-treated GBP is a graft material that can be...Continue Reading

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