Osteogenic protein-1 enhances osseointegration of titanium implants coated with peri-apatite in rabbit femoral defect

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Renwen ZhangMonica Hawkins

Abstract

This study evaluated the effect of osteogenic protein-1 (OP-1) carried by Peri-Apatite (PA) on bone healing in the gap surrounding implants in a rabbit model. Cylindrical titanium implants (3 x 9 mm) were uniformly coated with PA precipitated from a calcium and phosphate solution. OP-1 solution containing 60 microg OP-1 was directly loaded on the implants immediately before implantation for the experimental group, whereas buffer solution was loaded on the implants for the control. The implant was placed in the distal femur and surrounded by a 1-mm gap. The implants were retrieved and examined 6 weeks after implantation. Mechanical testing (push-out) data showed that OP-1 enhanced implant fixation by 80%. Histomorphometric measurements indicated that bone ingrowth in the initial gap expressed as a percentage of the whole gap was significantly higher in the specimens treated with OP-1 than the control group (25.4% vs. 8.9%, p < 0.05). The percentage of the surface of implants, which was covered by bone, was significantly higher in the OP-1-treated group compared to the control group (65% vs. 25%, p < 0.05). This study suggests that OP-1 can be loaded on orthopedic implants through PA to enhance the osseointegration of orthopedic ...Continue Reading

References

Mar 1, 1992·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K SøballeC Bünger
May 1, 1992·The Journal of Bone and Joint Surgery. British Volume·M J CurtisD S Hungerford
Jan 1, 1988·The Journal of Bone and Joint Surgery. British Volume·R G GeesinkC P Klein
Aug 1, 1995·The Journal of Bone and Joint Surgery. American Volume·D R SumnerJ O Galante
May 1, 1995·The Journal of Bone and Joint Surgery. American Volume·S D CookD C Rueger
Jan 1, 1995·The Journal of Bone and Joint Surgery. American Volume·J E DaltonJ F Kay
Jun 1, 1994·The Journal of Bone and Joint Surgery. American Volume·S D CookT S Whitecloud
Feb 14, 1998·Acta Orthopaedica Scandinavica·D E AndersonJ J Hoskinson
Jun 24, 1999·Journal of Biomedical Materials Research·H UludagJ Wozney
Apr 4, 2002·Acta Orthopaedica Scandinavica·Thomas B JensenKjeld Søballe
May 15, 2002·Clinical Oral Implants Research·Johan W M VehofJohn A Jansen
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·John Louis-UgboSteve Peckham

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Citations

Jul 8, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Weiping RenDavid C Markel
Jan 10, 2012·International Journal of Nanomedicine·Wei SongWeiping Ren
Sep 5, 2006·Expert Opinion on Drug Delivery·Darnell KaiglerWilliam V Giannobile
May 15, 2007·Advanced Drug Delivery Reviews·Eduardo K MoioliJeremy J Mao
Jun 1, 2011·Journal of Biomedical Materials Research. Part a·Wei SongDavid C Markel
Dec 19, 2013·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Weiping P RenDavid C Markel
Sep 29, 2005·Injury·Rozalia Dimitriou, Peter V Giannoudis
Dec 22, 2007·Nanomedicine·Robert M StreicherSilvana Fiorito
May 18, 2011·Clinical Orthopaedics and Related Research·Weiping Ren, David C Markel
Mar 10, 2010·Journal of Orthopaedic Trauma·Peter V Giannoudis, Haralampos T Dinopoulos
Jan 17, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paul A ClarkJeremy J Mao
Sep 30, 2010·Clinical Orthopaedics and Related Research·Neil SaranRobert E Turcotte
Apr 6, 2011·The Journal of Bone and Joint Surgery. British Volume·X H XieL Qin
Nov 26, 2009·The Orthopedic Clinics of North America·Peter V Giannoudis, Haralampos T Dinopoulos
Nov 9, 2010·Foot and Ankle Clinics·Peter V Giannoudis, Haralampos T Dinopoulos

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