Osteogenic protein-1 mRNA in the uterine endometrium

Biochemical and Biophysical Research Communications
E OzkaynakH Oppermann

Abstract

OP-1, a bone morphogenetic protein (BMP) in the TGF-beta superfamily, is expressed at high levels in the kidney and in the endometrium of the uterus of non-pregnant mice. During pregnancy the OP-1 mRNA in the endometrium rapidly declined at 4 dpc. Thereafter, OP-1 transcripts were detected in the trophoblastic giant cells of the placenta and the fetal tissues. The uterine OP-1 mRNA downregulation could be mimicked by administration of 17 beta-estradiol but not by progesterone to non-pregnant animals. In contrast, OP-1 mRNA expression in kidneys and ovaries was not affected by pregnancy or estrogen treatment. The selective effect of estrogen on OP-1 mRNA in the uterus suggests that OP-1 expression is regulated by tissue specific mechanisms.

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Citations

Mar 20, 2012·Cell and Tissue Research·Toshihiko EzashiR Michael Roberts
Aug 30, 2008·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Gerard K JeongJames Farmer
Jun 10, 2000·Molecular and Cellular Biology·D G MonroeM M Sanders
Aug 4, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Pradeep S Tanwar, James R McFarlane
Jun 21, 2001·Proceedings of the National Academy of Sciences of the United States of America·S E YiK M Lyons
Mar 28, 2008·Journal of Neurochemistry·Bradley J Walters, Colin J Saldanha
Feb 11, 2011·Journal of Cellular Biochemistry·Shinong Wang, Raimund Hirschberg
Jan 25, 2002·Journal of Cellular Physiology·V M ParalkarD D Thompson
Mar 3, 2004·Journal of Biochemical and Molecular Toxicology·Takahiro KusumegiHideko Sone
Feb 11, 2004·Endocrine Reviews·Shunichi ShimasakiGregory F Erickson
Jan 16, 2015·American Journal of Physiology. Cell Physiology·Hirotaka TasakiMasa-aki Hattori

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