Osteogenic sarcoma: noninvasive in vivo assessment of tumor necrosis with diffusion-weighted MR imaging

Radiology
P LangH K Genant

Abstract

To evaluate diffusion-weighted magnetic resonance (MR) imaging for detecting tumor necrosis in an animal model of osteogenic sarcoma. Twelve rats with osteogenic sarcoma underwent T1-weighted unenhanced and gadolinium-enhanced spin-echo and diffusion-weighted spin-echo MR imaging. Histologic correlation was performed. Signal intensities, T2 relaxation times, normalized apparent diffusion coefficients, and relative signal intensity increases were calculated. On diffusion-weighted images, necrotic tumor showed low signal intensity (mean normalized apparent diffusion coefficient, 0.46 +/- 0.20 [1 standard deviation]), indicating rapid diffusion of water molecules as a result of loss of membrane integrity, while viable tumor showed high signal intensity (mean normalized apparent diffusion coefficient, 0.16 +/- 0.05; P < .0001). Differences in the T2 relaxation times and relative signal intensity increases between viable and necrotic tumor were not statistically significant. Normalized apparent diffusion coefficients are more accurate in differentiating between viable and necrotic tumor than are T2 relaxation times or relative signal intensity increases on contrast-enhanced images. Signal intensity overlap between viable and necroti...Continue Reading

Citations

Oct 1, 2010·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·P Murphy, D-M Koh
Oct 16, 2008·World Journal of Gastroenterology : WJG·Zhao-Xia JiangHong-Feng Lu
Feb 3, 2011·World Journal of Radiology·Huaijun WangYicheng Ni
Jan 22, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Bassel AtassiRiad Salem
Feb 18, 2014·Abdominal Imaging·Reena C JhaSunder Rajan
Jan 9, 2007·European Radiology·Harriet C Thoeny, Frederik De Keyzer
May 30, 2003·Radiology·Diego JaramilloFrederic Shapiro
Dec 4, 2002·Radiology·Andreas M HernethHerwig Imhof
Mar 23, 2007·AJR. American Journal of Roentgenology·Dow-Mu KohJanet E Husband
May 23, 2007·AJR. American Journal of Roentgenology·Dow-Mu Koh, David J Collins
May 22, 2010·AJR. American Journal of Roentgenology·Chan Kyo KimBohyun Kim
Apr 7, 2009·Investigative Radiology·Wilfried ReichardtUdo Kontny
Mar 14, 2002·Journal of Magnetic Resonance Imaging : JMRI·Catherina S P van RijswijkJohan L Bloem
Oct 3, 2002·Topics in Magnetic Resonance Imaging : TMRI·Ihab R Kamel, David A Bluemke
Sep 1, 2007·Topics in Magnetic Resonance Imaging : TMRI·Andreas M HernethHerwig Imhof
Mar 11, 2008·Current Opinion in Otolaryngology & Head and Neck Surgery·Peter ZbärenHarriet C Thoeny
Jun 29, 2007·Pediatric Radiology·John D MacKenzieDiego Jaramillo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.