PMID: 9180230Jun 1, 1997Paper

Osteogenic sarcoma of the jaws: factors influencing prognosis

International Journal of Oral and Maxillofacial Surgery
Meredith AugustD Dewitt

Abstract

Thirty cases of osteosarcoma of the jaws were reviewed (20 men and 10 women, mean age 34 years). Seventeen lesions occurred in the mandible and 13 in the maxilla. Swelling without pain was the most common presenting symptom. Thirteen lesions were initially misdiagnosed as odontogenic infections. Numbness as a presenting symptom was statistically associated with poor prognosis. Treatment included all combinations of surgery, chemotherapy and radiotherapy. Patients receiving chemotherapy with four or more agents showed a trend toward better survival with 71% alive and disease-free at the time of review. Patients' increasing age was statistically associated with decreased survival. The average age of survivors was 27 years and nonsurvivors, 40 years. Older patients suffered more local recurrences which, in all but one case, resulted in mortality. Expectedly, clear surgical margins correlated statistically with improved survival. With margins of less than 5 mm, 27% of patients were alive and disease-free as compared to 62% with surgical margins greater than 5 mm. The importance of early diagnosis, definitive surgical treatment and aggressive adjuvant chemotherapy is demonstrated. The Proportional Hazards Regression model was employ...Continue Reading

References

Mar 15, 1990·Cancer·A M KurtD J Pritchard
Feb 1, 1986·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·H A AjagbeJ O Daramola
Aug 1, 1986·Oral Surgery, Oral Medicine, and Oral Pathology·G FortezaF López-Barea
Jun 19, 1986·The New England Journal of Medicine·M P LinkJ A Kirkpatrick
Feb 1, 1985·Mayo Clinic Proceedings·W F TaylorJ H Edmonson
Aug 1, 1985·Journal of Maxillofacial Surgery·P J Slootweg, H Müller
Dec 26, 1985·The New England Journal of Medicine·A M GoorinE Frei
Mar 1, 1967·Cancer·G E GarringtonS P Hooker
Apr 1, 1967·Southern Medical Journal·C A RockwoodG C Branam
Dec 1, 1971·American Journal of Surgery·A S CaronE W Strong
Jun 15, 1983·Cancer·J L ClarkK D Devine
Jan 1, 1983·Journal of Cancer Research and Clinical Oncology·G RosenS Groshen
Oct 1, 1980·American Journal of Surgery·J E Russ, R H Jesse
Dec 1, 1980·Oral Surgery, Oral Medicine, and Oral Pathology·J M BrasI van der Waal
Oct 1, 1958·American Journal of Surgery·L V KRAGHJ B ERICH

❮ Previous
Next ❯

Citations

Nov 16, 2010·Head and Neck Pathology·Márcio Ajudarte LopesPablo Agustin Vargas
Sep 1, 2009·Journal of Maxillofacial and Oral Surgery·C KumaraveluK Sridhar Reddy
Dec 31, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Eric R CarlsonJon D Holmes
Mar 3, 2005·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Eiji NakayamaShigenobu Kanda
Sep 21, 2001·Oral Oncology·M L Chindia
Feb 7, 2003·Oral Oncology·Yi-Shing Lisa ChengMaxwell D Finn
May 16, 2003·Oral Oncology·Ademar Takahama JuniorMárcio Ajudarte Lopes
Feb 15, 2011·Skull Base : Official Journal of North American Skull Base Society ... [et Al.]·Marton KönigTorstein R Meling
Apr 20, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·O MardingerS Taicher
Oct 27, 2010·The American Journal of Surgical Pathology·Elizabeth G DemiccoAndrew E Rosenberg
Dec 2, 2010·The Journal of Craniofacial Surgery·Kuauhyama Luna-OrtizAdalberto Mosqueda-Taylor
May 12, 2011·The Journal of Craniofacial Surgery·Shahin Mohammad Sadeghi, Seyed Nejat Hosseini
May 19, 2011·The Journal of Craniofacial Surgery·Hong Hai FuYue He
May 15, 2004·Journal of Oral Science·Siew-Tin OngChong-Huat Siar
Aug 28, 2012·Journal of Oral and Maxillofacial Pathology : JOMFP·Mayur Chaudhary, Shweta Dixit Chaudhary
Jan 4, 2013·Journal of Clinical and Diagnostic Research : JCDR·Jitendra V KalburgeYogesh Kini
Dec 18, 2012·Case Reports in Dentistry·Sukumaran AnilR Rajendran
Jun 1, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Natacha KadlubArnaud Picard
Nov 15, 2011·Dento Maxillo Facial Radiology·S WangQ Yu
May 18, 2005·Dento Maxillo Facial Radiology·E NakayamaK Yoshiura
Sep 6, 2011·Oral and Maxillofacial Surgery·Pedro Ivo Machado Pires de AraújoLuiz Augusto Nascimento
Sep 17, 2013·International Journal of Oral and Maxillofacial Surgery·H van den Berg, J H M Merks
Nov 20, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yu-Lin JiaHan-Dong Zhang
Nov 16, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Peer Wolfgang KämmererBilal Al-Nawas
Aug 27, 2011·Critical Reviews in Oncology/hematology·Juliette ThariatNicolas Isambert
Feb 4, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Megan Granowski-LeCornuMeredith August
Apr 27, 2010·The British Journal of Oral & Maxillofacial Surgery·A KetabchiL Newman
Sep 16, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Robert J LeeRussell E Christensen
Sep 1, 2012·Veterinary and Comparative Oncology·N FarcasF J M Verstraete
Jun 9, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Tao-Tao SunHui-Min Shi
Jan 7, 2004·International Journal of Paediatric Dentistry·M E DonaldsonT D Daley
Jan 24, 2007·Oral Diseases·E H NissankaW M Tilakaratne
Apr 22, 2009·Cancer·B Ashleigh GuadagnoloErich M Sturgis
May 2, 2014·Journal of Plastic Surgery and Hand Surgery·Asuman ArgonFikri Öztop
Apr 26, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Nikolaos G NikitakisNikos Papadogeorgakis
May 1, 2007·Oral Oncology·Sven JasnauUNKNOWN Cooperative Osteosarcoma Study Group COSS
Jan 21, 2000·Cancer·F DuffaudR Favre
Oct 28, 2011·Brazilian Oral Research·Rafael Morales VadilloJanet Ofelia Guevara Canales
Nov 17, 2017·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Hye-In JeongHyung Jun Kim
Sep 19, 2002·Cancer·Snehal G PatelDennis H Kraus
Oct 20, 2018·Journal of Pediatric Hematology/oncology·Christopher Kuo, Paul M Kent

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics
O MardingerS Taicher
Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Rui FernandesRobert A Ord
Oral Surgery, Oral Medicine, and Oral Pathology
G FortezaF López-Barea
© 2021 Meta ULC. All rights reserved