PMID: 9430300Jan 16, 1998Paper

Osteogenin-enhanced bone-specific differentiation in hydroxyapatite orbital implants

Ophthalmic Plastic and Reconstructive Surgery
B S SiresA H Reddi

Abstract

Hydroxyapatite orbital implants undergo early ingrowth of fibrovascular tissue after enucleation. This animal study determined whether control and osteogenin-impregnated hydroxyapatite orbital implants vary in their osteogenic response at 6 and 52 weeks. Rabbits underwent enucleation with implantation of control or osteogenin-impregnated hydroxyapatite spheres. Light microscopy determined fibrovascular ingrowth, and histomorphometry quantitated the amount of bone produced. Osteogenin implants vascularized at a faster rate and contained bony foci by 6 weeks that became confluent at 1 year. Spontaneous osteogenesis was not seen in control animals at 6 weeks. After 1 year they contained bone, although less than in the osteogenin implants. Mixed cell inflammation was observed at the hydroxyapatite-tissue interface in both groups. No inflammation was noted at the interface of hydroxyapatite and bone. These are the first controlled observations that bone-specific differentiation occurs in the pores of spherical hydroxyapatite implants within the soft tissues of the socket. This vascularized process can be enhanced with osteogenin to occur earlier and more uniformly in the implants at one year.

Citations

Nov 16, 2001·Journal of the American College of Surgeons·N ShorrT Cook
Feb 10, 2000·Survey of Ophthalmology·D M MoshfeghiP T Finger
Jul 21, 2009·Tissue Engineering. Part a·Minal PatelJohn P Fisher
Sep 3, 1999·The Orthopedic Clinics of North America·E C Shors
Oct 6, 2000·American Journal of Ophthalmology·B S Sires, P M Benda
Oct 6, 2000·Ophthalmic Plastic and Reconstructive Surgery·P L Custer
Apr 15, 2004·Ophthalmic Plastic and Reconstructive Surgery·David R Jordan
Mar 22, 2006·Ophthalmic Plastic and Reconstructive Surgery·Hee Young ChoiBoo Sup Oum
Apr 25, 2001·Journal of Biomedical Materials Research·H YuanK de Groot

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