Osteoimmunological aspects of periodontal inflammatory destructive changes at periimplantitis, chronic periodontitis and oncological diseases of the oral cavity

Stomatologii︠a︡
O A ZorinaA A Demidova

Abstract

Was to analyze possible correlation between the concentration of the pro-inflammatory cytokine interleukin-6 and the activation marker of osteoclasts cathepsin K in the gingival fluid during osteoresorption of inflammatory (periimplantitis, chronic generalized periodontitis) and malignant oncological origin (malignant neoplasm of gums). The study comprised 87 individuals of both sexes aged 30 to 60: 20 patients (group 1) with periimplantitis, 30 people with chronic generalized periodontitis (CGP) (group 2), 22 patients with squamous cell carcinoma of the upper and lower alveolar bone gingiva (group 3), 15 healthy individuals without periodontal disease. The concentration of interleukin-6 (IL-6) and cathepsin K was determined in the gingival fluid by enzyme-linked immunosorbent assay. The examination revealed that during CGP and peri-implantitis the accumulation of IL-6 in the contents of periodontal and peri-implantation pockets was a pathogenetic factor for the activation of osteoclasts and their secretion of proteolytic enzymes osteoresorption. In cancer the increase of cathepsin K expression was a lot higher than the accumulation of IL-6 in the gingival fluid reducing the dependence of the activation of osteoclasts on the lo...Continue Reading

References

Sep 9, 2008·Journal of Clinical Periodontology·Jan LindheUNKNOWN Group D of European Workshop on Periodontology
Nov 27, 2010·Journal of Periodontal Research·S VerardiS Bordin
Nov 5, 2011·Oral Diseases·L NibaliN Donos
Oct 17, 2012·Nature Reviews. Rheumatology·Hiroshi Takayanagi
Mar 6, 2013·Biochemia Medica·Janja ZupanJanja Marc
Mar 29, 2018·Calcified Tissue International·Asuka Terashima, Hiroshi Takayanagi
Mar 5, 2019·Stomatologii︠a︡·O A ZorinaE S Maksyukova

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