PMID: 8961028Oct 1, 1996Paper

Osteoinductive potential of freeze-dried, biodegradable, poly (glycolic acid-co-lactic acid) disks incorporated with bone morphogenetic protein in skull defects of rats

International Journal of Oral and Maxillofacial Surgery
T Miki, Y Imai

Abstract

Biodegradable, porous, polymer implant disks with an osteoinductive potential were prepared by a freeze-drying technique by incorporating bovine bone morphogenetic protein (BMP) in poly (glycolic acid-co-lactic acid) (PGLA). The PGLA disks with and without BMP were implanted in rat skull defects, and the defect sites were studied radiographically and histologically for 2 and 4 weeks after implantation. A quantitative radiographic analysis showed significantly thicker radiopacity for the disks with BMP than those without BMP (P < 0.01). After 2 weeks, chondrogenesis and new bone formation were observed on the BMP-incorporated disks. After 4 weeks, PGLA was completely replaced by new bone in the defects with implantation of the BMP-incorporated disks, whereas the defects implanted with PGLA alone were filled with fibrous connective tissue. The results suggest that BMP-incorporated PGLA is an ideal bone substitute with osteoinductive potential.

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Citations

Sep 1, 2000·Advanced Drug Delivery Reviews·C A Kirker-Head
Mar 26, 2008·The Journal of Craniofacial Surgery·Yong-Chen PorLynne A Opperman
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Vuk Uskoković
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Jul 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yong-Il ChungGiyoong Tae
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Jul 27, 2001·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·T MikiS Enomoto

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