Abstract
Biodegradable, porous, polymer implant disks with an osteoinductive potential were prepared by a freeze-drying technique by incorporating bovine bone morphogenetic protein (BMP) in poly (glycolic acid-co-lactic acid) (PGLA). The PGLA disks with and without BMP were implanted in rat skull defects, and the defect sites were studied radiographically and histologically for 2 and 4 weeks after implantation. A quantitative radiographic analysis showed significantly thicker radiopacity for the disks with BMP than those without BMP (P < 0.01). After 2 weeks, chondrogenesis and new bone formation were observed on the BMP-incorporated disks. After 4 weeks, PGLA was completely replaced by new bone in the defects with implantation of the BMP-incorporated disks, whereas the defects implanted with PGLA alone were filled with fibrous connective tissue. The results suggest that BMP-incorporated PGLA is an ideal bone substitute with osteoinductive potential.
References
Sep 1, 1977·Journal of Biomedical Materials Research·R A MillerD E Cutright
Nov 1, 1992·Plastic and Reconstructive Surgery·I OnoY Kuboki
Jun 1, 1992·The Journal of Bone and Joint Surgery. American Volume·A W YaskoE A Wang
Dec 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·E M PinholtE Sudmann
Nov 1, 1991·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K TakaokaH Nakahara
Jan 1, 1990·The Journal of Craniofacial Surgery·J O Hollinger, J C Kleinschmidt
Dec 1, 1990·Journal of Periodontology·B A DollJ T Mellonig
Jun 1, 1990·International Journal of Oral and Maxillofacial Surgery·J C MooreE J Miller
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·E A WangP LaPan
Jan 1, 1988·Microsurgery·J B Boyd
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E A WangJ M Wozney
Dec 16, 1988·Science·J M WozneyE A Wang
Mar 1, 1987·Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan·I Asahina
Jun 1, 1987·Clinical Orthopaedics and Related Research·D FergusonE P Allen
Nov 12, 1965·Science·M R Urist
Oct 1, 1994·Journal of Biomedical Materials Research·R KenleyJ O Hollinger
Jun 1, 1994·Biomaterials·M C MeikleJ J Reynolds
Apr 1, 1994·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·L K CheungH Tideman
Apr 1, 1994·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·T MikiS Enomoto
Dec 1, 1993·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·A A Taher
Mar 1, 1993·Kōkūbyō Gakkai zasshi. The Journal of the Stomatological Society, Japan·N Sakurai
Apr 1, 1993·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·R SchmelzeisenJ Brennwald
Dec 10, 1991·Clinical Materials·M VertH Garreau
Citations
Jul 6, 2000·Journal of Biomedical Materials Research·Y NakayamaT Matsuda
May 26, 2001·Biomaterials·M I AlamS Enomoto
May 30, 2002·Biomaterials·M AraY Imai
Sep 1, 2000·Advanced Drug Delivery Reviews·C A Kirker-Head
Sep 25, 1999·Human Gene Therapy·T D AldenG A Helm
Mar 26, 2008·The Journal of Craniofacial Surgery·Yong-Chen PorLynne A Opperman
Sep 12, 2015·Materials Science & Engineering. C, Materials for Biological Applications·Vuk Uskoković
Oct 24, 2007·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Leigh JonesBirte Melsen
Jul 3, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yong-Il ChungGiyoong Tae
Jun 9, 2012·Journal of Tissue Engineering and Regenerative Medicine·Cheryl V RahmanErella Livne
Sep 29, 2006·International Journal of Oral and Maxillofacial Surgery·H InodaT Hattori
Nov 9, 2000·International Journal of Oral and Maxillofacial Surgery·S WeiheH Eufinger
Nov 27, 1999·Journal of Dental Research·S KamakuraK Motegi
Jul 17, 2001·Artificial Organs·H SuhC D Han
Aug 9, 2006·Journal of Biomaterials Science. Polymer Edition·Christina GretzerPeter Thomsen
Mar 3, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Long BiRong Lv
Jul 27, 2001·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·T MikiS Enomoto