PMID: 4286341Mar 11, 1966Paper

Osteolytic sterol in human breast cancer

Science
G S GordonW Lubich

Abstract

Eleven of twelve human breast cancers contained a lipid which increased urinary (45)Ca and (40)Ca excretion of (45)Ca-labeled, parathyroidectomized rats receiving a low Ca diet. The lipid has mobility on thin-layer chromatography and gas-liquid chromatography close to, but not identical with, that of 7-dehydrocholesterol. Authentic 7-dehydrocholesterol has osteolytic activity similar to that of the extracted sterol. Fluorescence and Lieberman-Burchard reactions of the extracted sterol are similar to those of 7-dehydrocholesterol. The lipid was found by thin-layer chromatography in the extracts which had osteolytic activity. Neither the lipid nor osteolytic activity was found in extracts of tissue from two normal human breasts.

References

Jan 1, 1965·Annual Review of Medicine·B F BOWER, G S GORDAN
May 1, 1963·Proceedings of the National Academy of Sciences of the United States of America·S A BersonJ T Potts

❮ Previous
Next ❯

Citations

Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·H ArpsG Klöppel
Oct 30, 1978·Life Sciences·G R Mundy
Mar 1, 1990·Baillière's Clinical Endocrinology and Metabolism·G E GutierrezG R Mundy
Apr 18, 1974·The New England Journal of Medicine·G R MundyD N Buell
Apr 18, 1974·The New England Journal of Medicine·A H Tashjian
Nov 14, 1974·The New England Journal of Medicine·H B Brewer
Jul 1, 1974·Clinical Endocrinology·L H Rees, J G Ratcliffe
Nov 1, 1984·Acta Pathologica Japonica·H KobayashiM Tamura
Nov 1, 1972·The Journal of Obstetrics and Gynaecology of the British Commonwealth·J D Rivett, J M Robinson
Feb 28, 1970·British Medical Journal
Nov 1, 1969·Journal of Clinical Pathology·J G Azzopardi, R S Whittaker
Jan 1, 1980·Postgraduate Medical Journal·M Greaves, B W Hancock
Jan 1, 1974·Annals of the New York Academy of Sciences·G S Gordan
Jan 1, 1974·Annals of the New York Academy of Sciences·J X Laurent, R E Jeanpierre
Jul 1, 1980·Clinics in Endocrinology and Metabolism·R S Bockman
Jan 1, 1991·Bone·G R Mundy
Aug 1, 1969·Metabolism: Clinical and Experimental·E A DayM F Beeler
May 1, 1978·The American Journal of Medicine·J E GittmanY S Arkel
Jun 1, 1979·American Journal of Surgery·M E Burt, M F Brennan
Apr 1, 1979·Gynecologic Oncology·C G Lacey, C P Morrow
Jun 1, 1989·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·U H Lerner, B Ljungberg
Jul 1, 1974·Clinics in Endocrinology and Metabolism·R Buckle
Apr 1, 1976·Chest·O L SilvaR H Snider
Jun 1, 1978·Cancer·A Besarab, J F Caro
Apr 1, 1971·Cancer·C M HaskellG P Canellos
Jun 1, 1975·Journal of Dental Research·W C Sturtridge
Jun 1, 1975·Journal of Dental Research·A S PosnerF Betts
May 1, 1978·The Journal of Urology·H A McKayG A Le Blanc
May 15, 1975·Klinische Wochenschrift·H G HaasJ Guncaga
Jan 1, 1979·Journal of the Royal Society of Medicine·D AtkinsT J Martin
Sep 1, 1975·Scandinavian Journal of Haematology·K Norrby, O Vikrot

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.