Osteomyelitis of the foot in diabetic patients

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
B A Lipsky

Abstract

Osteomyelitis of the foot, a common and serious problem in diabetic patients, results from diabetes complications, especially peripheral neuropathy. Infection generally develops by spread of contiguous soft-tissue infection to underlying bone. The major diagnostic difficulty in diabetic patients is distinguishing bone infection from noninfectious neuropathic bony lesions. Certain clinical signs suggest osteomyelitis, but imaging tests are usually needed. The 111In-labeled leukocyte scan and magnetic resonance imaging are the most diagnostically useful. Staphylococcus aureus is the most common etiologic agent, followed by other aerobic gram-positive cocci. Aerobic gram-negative bacilli and anaerobes are occasionally isolated, often in mixed infections. Antimicrobial therapy is best directed by cultures of the infected bone, obtained percutaneously or at surgery. Antibiotic therapy should usually be given parenterally, at least initially, and continued for at least 6 weeks. Surgical debridement or resection of the infected bone, when feasible, improves the outcome. With appropriate therapy most cases of osteomyelitis can be successfully managed.

Associated Clinical Trials

Citations

Oct 21, 2005·Advances in Therapy·Thomas Zgonis, Thomas S Roukis
Feb 26, 2009·Skeletal Radiology·Vartan M VartaniansDaniel I Rosenthal
Jan 31, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Shabana SaeedJaved Irfanullah
Dec 6, 2005·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·M-F LutzF Lucht
Nov 13, 2004·Current Diabetes Reports·Anthony R Berendt, Benjamin Lipsky
Aug 29, 2006·Current Infectious Disease Reports·Warren S Joseph
Nov 30, 2000·Current Infectious Disease Reports·B A Lipsky
Nov 30, 2000·Current Infectious Disease Reports·H Sax, D Lew
May 24, 2000·Comprehensive Therapy·D M Bamberger
Dec 20, 2003·American Journal of Surgery·Robert G Frykberg
Dec 7, 2010·International Journal of Surgery·T P ElamuruganSubhash Chandra Parija
May 10, 2003·Lancet·William J Jeffcoate, Keith G Harding
Sep 26, 2001·Infectious Disease Clinics of North America·H G Deery, J A Sangeorzan
Dec 21, 2006·Nature Clinical Practice. Endocrinology & Metabolism·Haris M Rathur, Andrew J M Boulton
Dec 17, 2009·Nature Reviews. Endocrinology·Fran Game
Oct 27, 2001·Diabetic Medicine : a Journal of the British Diabetic Association·G PellizzerF de Lalla
Jun 23, 2010·Seminars in Plastic Surgery·Catherine M Hannan, Christopher E Attinger
Dec 18, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A LipskyUNKNOWN Linezolid Diabetic Foot Infections Study Group
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A Lipsky
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·William J Jeffcoate, Benjamin A Lipsky
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gary L Simon, Angelike P Liappis
Oct 9, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A LipskyUNKNOWN Infectious Diseases Society of America
Jan 24, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Lawrence A LaveryBenjamin A Lipsky
Jul 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Marie T DinhNasia Safdar
Jul 10, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A Lipsky
May 1, 2004·Diabetes Technology & Therapeutics·David G Armstrong, Benjamin A Lipsky
Jun 14, 2012·Diabetes Technology & Therapeutics·Nadeem ParvezAnil Bhansali
Oct 12, 2010·The Journal of Antimicrobial Chemotherapy·Andrew S Powlson, Anthony P Coll
Aug 9, 2006·Nuclear Medicine Communications·Laura Giurato, Luigi Uccioli
Jun 27, 2006·Plastic and Reconstructive Surgery·Benjamin A LipskyUNKNOWN Infectious Diseases Society of America
Oct 16, 2007·International Journal of Clinical Practice·A Shojaie FardB Larijani
Oct 21, 2004·Drugs & Aging·Edward B Jude, Philip F Unsworth
Feb 8, 2007·Drugs·Nalini Rao, Benjamin A Lipsky
Jan 9, 2001·PharmacoEconomics·G R TennvallM Eneroth
Oct 11, 2012·Diabetic Foot & Ankle·S Eser SanverdiAli Oznur
Oct 11, 2012·Diabetic Foot & Ankle·Abubakr H WidatallaMohamed Elmakki Ahmed
May 17, 2006·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Christopher J PalestroJosephine N Rini
Jul 31, 2013·Journal of Tissue Viability·Hashim MohamedSeham Abdi
Jun 6, 2014·Journal of the American Podiatric Medical Association·Yakup Barbaros BaykalMustafa Yıldız
May 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Benjamin A Lipsky Infectious Diseases Society of America
Nov 15, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Jonathan C BakerDavid A Rubin
May 14, 2010·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Andrea Donovan, Mark E Schweitzer

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