Osteonecrosis 15 years after femoral neck fracture and long-term low-dose inhaled corticosteroid therapy

Joint, Bone, Spine : Revue Du Rhumatisme
Kai KisielinskiFritz-Uwe Niethard

Abstract

Posttraumatic avascular necrosis of the femoral head typically occurs immediately or within a few years after a femoral neck injury, and non-traumatic avascular necrosis is often related to systemic glucocorticoid therapy. We report an unusual case in which avascular necrosis of the femoral head occurred 15 years after a transcervical femoral fracture in a woman with a 20-year history of daily inhaled glucocorticoid therapy for chronic bronchitis. She had not taken glucocorticoids by any other route and had no other risk factors for osteonecrosis. To our knowledge, this is the first report of osteonecrosis associated with inhaled glucocorticoid therapy in a patient with a local cause of diminished vascular reserve. Inhaled glucocorticoid therapy should be added to the list of risk factors for osteonecrosis.

References

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Citations

Sep 11, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David Weldon
Aug 2, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Pinar CeGulriz Ozbek
Jun 25, 2005·Clinical Journal of Oncology Nursing·Pamela Hallquist Viale, Albert Lin
Jun 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giampaolo TalamoElias Anaissie

Related Concepts

Inhalation of Drugs
Bronchocort
Femoral Neck Fractures
Aseptic Necrosis of Femur Head
Glucocorticoid Effect
Diagnostic Radiologic Examination

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