Osteonecrosis in SLE: prevalence, patterns, outcomes and predictors

Lupus
D D GladmanM B Urowitz

Abstract

Objective Osteonecrosis is a serious comorbidity in patients with systemic lupus erythematosus. The aims of this study were to describe the prevalence of symptomatic osteonecrosis, determine the pattern of joint involvement, identify the outcomes and investigate predictive factors in a large cohort of patients with systemic lupus erythematosus followed prospectively. Methods At the Toronto Lupus Clinic patients have been followed prospectively according to a standard protocol since 1970. Osteonecrosis is recorded if patients are symptomatic and is confirmed by imaging. The site of osteonecrosis is recorded and whether or not surgery was performed. For determination of prevalence, pattern and outcome of osteonecrosis a longitudinal cohort design was performed. For the predictive factors, only patients with incident osteonecrosis were included and were matched for gender, year of entry to clinic (within 5 years), year of birth (within 5 years) and disease duration (within 3 years) with systemic lupus erythematosus patients without osteonecrosis. Results Of 1729 patients with systemic lupus erythematosus registered in the database, 234 (13.5%) developed symptomatic osteonecrosis in 581 sites. Hips and knees were most commonly affe...Continue Reading

References

Jun 10, 2003·Clinical Reviews in Allergy & Immunology·Mahmoud Abu-ShakraYehuda Shoenfeld
Aug 17, 2010·Rheumatology International·Mehmet SayarliogluOrhan Aral
Jan 1, 2010·Saudi Journal of Biological Sciences·Faris Q AlenziRichard K H Wyse
Nov 17, 2015·The Journal of Rheumatology·Yelin YangDeborah M Levy

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Citations

Oct 29, 2020·Journal of Family Medicine and Primary Care·Saranya ChinnaduraiRajeswari Sankaralingam
Mar 6, 2021·Frontiers in Medicine·Juan M Mejía-Vilet, Isabelle Ayoub
Mar 31, 2021·Rheumatic Diseases Clinics of North America·David S PisetskyJennifer L Rogers
Nov 8, 2020·International Journal of Surgery Case Reports·Ihsan Oesman, Danarto Hari Adhimukti
May 7, 2021·Expert Review of Clinical Immunology·Wei QijiaoChen Zhihan
Jun 28, 2021·Rheumatology·Khalil I BourjiLisa Christopher-Stine
Jul 17, 2021·Current Rheumatology Reports·Andrea Di MatteoWalter Grassi

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Methods Mentioned

BETA
biopsy

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