Osteonecrosis of the Jaw and Angiogenesis inhibitors: A Revival of a Rare but Serous Side Effect

Current Medicinal Chemistry
Lorenzo AntonuzzoFrancesco Di Costanzo

Abstract

Osteonecrosis of the jaw (ONJ) is a rare treatment related side effect that was firstly described in 2002 through a case report in metastatic bone cancer patient treated with bisphosphonates (BPs) therapy. ONJ is defined as an eight weeks or longer clinical finding of exposed bone in the oral cavity without response to appropriate therapy. The diagnosis is mainly clinical but often requires a radiological confirmation with an orthopantomography. So it must be made by a dental specialist with sufficient experience on ONJ and requires a detailed anamnestic exploration of comorbidities and treatments history. In particular, ONJ affects a wide number of oncologic patients treated with BPs for bone metastatic cancers and, more recently, with anti-angiogenic drugs. The aim of this this paper is to describe diagnosis and classification of this rare but serious side effect and its pathophysiology. In particular, we provide a detailed description of clinical evidences upon the relationship between anti-angiogenic drugs and ONJ. Considering the evolving of cancer epidemiology with a greater number of cancer surviving patients, this side effect always deserves more attention. We conclude that ONJ must be always carefully investigated and ...Continue Reading

Citations

Jan 17, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Letizia ProcaccioFotios Loupakis
Sep 24, 2019·Pharmaceutical Biology·Lili TianGuofu Zhu
Jun 15, 2019·Oxford Medical Case Reports·Leandro J C OliveiraArtur Katz
Apr 4, 2021·Medicina·Saverio CapodiferroGianfranco Favia
Mar 27, 2018·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Tomoko HiguchiAkira Sasaki

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