Osteonecrosis of the Jaw Associated with Antiangiogenics in Antiresorptive-Naïve Patient: A Comprehensive Review of the Literature

BioMed Research International
Kununya PimolbutrS Fedele

Abstract

To review the available literature on medication-related osteonecrosis of the jaw (MRONJ) associated with antiangiogenics in antiresorptive-naïve individuals. A literature search was performed using MEDLINE via PubMed, EMBASE, and Web of Science in December 2017. We identified reports describing a total of 35 antiresorptive drugs-naïve patients who developed antiangiogenic-related MRONJ. The mean age of these patients was 59.06 years and the F : M ratio was 4 : 5. The most common underlying disease was metastatic renal cell cancer. Pain to the mandible was the most common complaint (34.29%) and the majority of patients presented with bone exposure. The mean duration of intravenous and oral antiangiogenics before MRONJ development was 6.5 and 16.72 months, respectively. The most common additional risk factor was dental extraction (37.14%). Almost half of the MRONJ patients (48.57%) received surgical treatment. 18 patients (62.06%) were reported to have disease resolution within an average time of 6.75 months. MRONJ associated with antiangiogenic therapy in antiresorptive-naïve patients is a rare but potentially serious adverse effect. Available data suggests that there might be notable differences between MRONJ associated with a...Continue Reading

References

Feb 7, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M S GordonD Adelman
Sep 11, 2003·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Robert E Marx
May 17, 2006·Annals of Internal Medicine·Sook-Bin WooJohn R Kalmar
Jun 3, 2006·Cancer Research·Donatella Del BufaloMichele Milella
Aug 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Cherry L EstiloJoseph M Huryn
Oct 28, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T Van den WyngaertE Fossion
Nov 4, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S GreuterB Thuerlimann
Mar 24, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Towy Sorel LazaroviciNoam Yarom
Apr 25, 2009·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroUNKNOWN American Association of Oral and Maxillofacial Surgeons
Oct 29, 2009·Journal of Hematology & Oncology·Ruirong YuanDavid Lebwohl
Nov 10, 2009·The Oncologist·Pinelopi Kleio PalaskaAthanasios I Zavras
Jan 16, 2010·International Journal of Immunopathology and Pharmacology·E SerraM Dolci
Apr 20, 2010·Oral and Maxillofacial Surgery·Felix P KochWilfried Wagner
May 29, 2010·Journal of Cancer Research and Clinical Oncology·O FilleulS Saussez
Sep 8, 2010·Cancer Treatment Reviews·Stéphane OudardPeter Albers
Nov 10, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alison T StopeckAda Braun
Jun 17, 2011·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Sven OttoChristoph Pautke
Jul 16, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Renato Nicolás HoppJacks Jorge
Apr 25, 2012·Oral Oncology·Sebastian KühlJ Thomas Lambrecht
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ourania Nicolatou-GalitisMeletios A Dimopoulos
Jun 9, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yoram FleissigHadas Lehman
Jun 19, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Michèle MagremanneHervé Reychler
Oct 13, 2012·International Journal of Immunopathology and Pharmacology·P Brunamonti BinelloL F Rodella
Oct 25, 2012·BMJ Case Reports·Giordana BettiniAlberto Bedogni
Dec 5, 2012·Pharmacotherapy·Belal Al-HuseinPayaningal R Somanath
Dec 18, 2012·Oral and Maxillofacial Surgery·Daria PakoschMarcus Stephan Kriwalsky
Feb 22, 2013·Journal of the National Cancer Institute·Michael GnantKathleen I Pritchard
Apr 10, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Alan Roger Santos-SilvaThaís Bianca Brandão
Jul 31, 2013·Oral Oncology·Nicole V HinchyMaureen A Sullivan
Aug 29, 2013·Mediators of Inflammation·So Young Yoo, Sang Mo Kwon
Feb 28, 2014·The Korean Journal of Internal Medicine·Sandro De Falco
Mar 25, 2014·Dental Clinics of North America·Jettie UyanneAnh D Le
Sep 23, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Salvatore L RuggieroFelice O'Ryan
Oct 6, 2014·The British Journal of Oral & Maxillofacial Surgery·Stefano FedeleAlberto Bedogni
Dec 5, 2014·Australian Dental Journal·R MarinoM Pentenero
Apr 29, 2015·Cancer Treatment Reviews·Issam S HamadehYan Gong
Aug 20, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Xiaoyan ZhangYan Gong
Feb 10, 2016·Journal of the National Cancer Institute·Lorenzo AntonuzzoFrancesco Di Costanzo
Apr 15, 2016·Expert Opinion on Drug Safety·V FuscoG Campisi

❮ Previous
Next ❯

Citations

Oct 26, 2018·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Ourania Nicolatou-GalitisUNKNOWN MASCC Bone Study Group
Oct 9, 2019·International Journal of Molecular Sciences·Alexandre AnesiAlexis Grande
Aug 23, 2020·Clinical Oral Investigations·R BachtlerRalf K W Schulze
Oct 17, 2020·Case Reports in Dentistry·Yosuke IijimaNorio Horie
Nov 15, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Lokendra GuptaSandeep V Gurav
Jun 13, 2021·British Dental Journal·Simon J LittlewoodSasan Naraghi

❮ Previous
Next ❯

Software Mentioned

MRONJ

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.