PMID: 9541258Apr 16, 1998Paper

Osteonectin RNA and collagen alpha1(I) RNA in the developing rat maxilla

European Journal of Oral Sciences
H LiaoT Wurtz

Abstract

The sequence of rat osteonectin mRNA was determined. Comparison with osteonectin (ON) mRNA sequences of other vertebrates showed a great similarity, but a stretch of codons deviated with respect to another rat strain, suggesting the possibility of two ON variants in rats. Northern blots exhibited one band of ON mRNA only. The expression of ON and collagen alpha1(I) RNA in tissues of the developing rat maxilla was studied by in situ hybridization. Both ON and collagen alpha1(I) RNA were observed concomitantly in osteoblasts, starting from the onset of bone formation at day 17 post coitum through the oldest age examined, day 20 after birth. A strict co-expression of the two sequences was also observed in odontoblasts as well as in fibroblasts of the periodontal ligament. In ameloblasts, neither ON nor collagen alpha1(I) RNA was detected under stringent hybridization conditions, but lower stringency led to an ON signal. Considering that ON is a secretory protein and the high stability of the ON mRNA, the co-expression of collagen alpha1(I) and ON RNA sequences in matrix-forming cells provided evidence that ON is a substantial component of collagen matrices.

Citations

Jun 27, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Issei KomatsubaraYasushi Shiratori
Mar 14, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anders KrügerTilmann Wurtz
Jun 18, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S C MarksS N Popoff
Nov 24, 2001·Molecular Biology and Evolution·S DelgadoM Girondot
Sep 1, 2018·BMC Evolutionary Biology·Sébastien EnaultMélanie Debiais-Thibaud
Jun 27, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Sophia HouariSylvie Babajko
Mar 7, 2000·Journal of the American Society of Nephrology : JASN·Sebastian WalpenJosef Pfeilschifter
Nov 20, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·T WurtzC Christersson

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