Osteopenia following total gastrectomy in the rat--state of mineral metabolism and bone histomorphometry

European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
G RümenapfW Hohenberger

Abstract

Total gastrectomy (GX) in humans is frequently followed by osteopenia, but the details are unclear. The present investigations in the rat were aimed at elucidating its pathogenesis. Seventeen weeks after GX, we evaluated Ca, Mg and P metabolism as well as bone parameters, including fluorochrome-based bone histomorphometry. In GX rats, fecal Mg was increased, but intestinal absorption of P, Ca, and Mg was within normal limits, as was the urinary excretion of Ca, Mg, hydroxyproline and the pyridinium cross-links. In contrast, urinary P as well as cyclic AMP were significantly increased. In serum of GX rats, gastrin and 25-hydroxyvitamin D (25-OHD) were decreased, and Ca, Mg, P, parathyroid hormone (PTH), calcitonin, and the bone marker osteocalcin were normal, whereas 1,25-dihydroxyvitamin D [1,25(OH)2D] was significantly increased. GX rats had significantly reduced bone density and mineral content, severe high-turnover osteopenia, characterized by normal width but significantly decreased maturation time of osteoid, increased bone formation rate, and increased numbers of osteoclasts. We concluded that after GX (1) there is high-turnover osteopenia with normal mineralization and other histomorphometric features resembling those se...Continue Reading

Citations

Jan 8, 1999·Regulatory Peptides·D Lehto-AxteliusO Johnell
Feb 24, 2001·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H GeppW Fries
Jul 1, 2014·Journal of Nutritional Science and Vitaminology·Jun IwamotoHideo Matsumoto
Nov 14, 2014·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M KrauseM Amling
Jun 20, 2013·Gastroenterology Research and Practice·Jun IwamotoHideo Matsumoto
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Jul 24, 2015·Experimental Biology and Medicine·Piotr DobrowolskiStefan G Pierzynowski
Jun 28, 2020·Endocrinology·Darshana DurupAnne-Marie Heegaard

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