PMID: 6169976Jan 1, 1981Paper

Osteopetro-rickets: a new congenital bone disorder

Metabolic Bone Disease & Related Research
G MilhaudM Juster

Abstract

Two lethal mutations have been described in the rat: "osteopetrosis" (op) and "toothless" (tl). The op mutant can be cured by normal bone marrow infusion, while the tl mutant cannot. We report here additional data with regard to the tl mutant. The bone disease of the tl rat as in the op rat is associated with a precocious thymic atrophy, but bone lesions are quite different. In addition to classical osteopetrosis, the tl rat displays several features of rickets: broadening of the extremities of long bones, thickening of the epiphyseal plates, presence of osteoid areas. In addition, the persistence of embryonic characters, evidenced by high levels of alpha-fetoprotein, suggests that the developmental defect of bone is part of a more general process.

References

Jan 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·G MilhaudL Chedid
Jul 1, 1967·The American Journal of Anatomy·D J Simmons, R L Simmons
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Citations

Nov 1, 1994·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M F Seifert
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G MilhaudY Moricard
Jan 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S N Popoff, S C Marks
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L C McCaryH F DeLuca
Oct 1, 1988·The American Journal of Anatomy·M F SeifertS C Marks
Feb 1, 1985·The American Journal of Anatomy·M F Seifert, S C Marks
Sep 1, 1989·American Journal of Medical Genetics·S C Marks
Dec 24, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Fatma DemirelBetul Tavil
Jan 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·G CournotM Garabedian

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