Osteopontin and alphavbeta3 integrin as markers of endometrial receptivity: the effect of different hormone therapies

Reproductive Biomedicine Online
Gemma CasalsJ Balasch

Abstract

The osteopontin: alphavbeta3 integrin complex has been proposed as a means of distinguishing receptive from non-receptive endometrium in clinical practice, thus offering new directions for the development of contraceptive approaches targeted to the endometrium as well as a better understanding of occult causes of infertility in women. Histological dating and immunohistochemical study were performed in control and study cycles in seven groups of women including 10 subjects per group and who received clomiphene citrate, ovarian stimulation for IVF, oral contraception, dehydrogesterone for endometrial luteal phase defect, two different regimens of hormone replacement therapy, or no treatment. Ten healthy fertile women served as a general control group. Osteopontin and alphavbeta3 integrin expression in the human endometrium was closely related to endometrial maturation and this was irrespective of the endometrium being in-phase or out-of-phase and the hormonal treatment (or no treatment) received. In conclusion, immunohistochemical assessment of the endometrium indicates that the use of osteopontin and alphavbeta3 integrin or the osteopontin: alphavbeta3 integrin complex as targets for the development of contraceptive approaches o...Continue Reading

References

Jun 1, 1992·American Journal of Obstetrics and Gynecology·A J PetersC B Coulam
Nov 30, 2000·The Journal of Clinical Endocrinology and Metabolism·N SantoroG Weiss
Feb 24, 2001·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·H Yaziji, A M Gown
May 22, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·Andrew M Sharkey, Stephen K Smith
Jul 28, 2004·American Journal of Reproductive Immunology : AJRI·Zdzisława Kondera-AnaszAleksandra Mielczarek-Palacz
Jan 27, 2005·Reproductive Biomedicine Online·Diederik A HoozemansPeter G A Hompes
Feb 8, 2005·Molecular & Cellular Proteomics : MCP·Mathias Uhlen, Fredrik Ponten
Apr 13, 2005·Reproductive Biomedicine Online·Vasilis MinasAntonis Makrigiannakis
Jun 2, 2006·Molecular & Cellular Proteomics : MCP·Nilofer S AzadElise C Kohn
Jul 13, 2006·Human Reproduction Update·Thomas StrowitzkiM von Wolff
Sep 20, 2006·Human Reproduction Update·Hanna Achache, Ariel Revel
Mar 31, 2007·Reproduction, Fertility, and Development·Sachin S Mangale, K V R Reddy
Nov 24, 2007·Seminars in Cell & Developmental Biology·L AghajanovaL C Giudice
Jun 14, 2008·Reproductive Biomedicine Online·Gemma CasalsJuan Balasch
Aug 2, 2008·Fertility and Sterility·Qingxiang WeiLynnette K Nieman
Mar 6, 2009·American Journal of Reproductive Immunology : AJRI·SiHyun ChoByung Seok Lee
Jun 27, 2009·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Paulo SerafiniEdmund Chada Baracat

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Citations

Sep 2, 2011·Fertility and Sterility·Bruce A Lessey
Feb 15, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Yuehui ZhangXiaoke Wu
Jan 8, 2016·Dose-response : a Publication of International Hormesis Society·Chiara MannelliLuana Paulesu
Jul 16, 2013·International Journal of Molecular Sciences·Qing-Zhen XieJing Yang
Jan 25, 2020·Expert Review of Clinical Pharmacology·Carlo BastianelliGiuseppe Benagiano
Feb 6, 2021·Reproduction, Fertility, and Development·Tina D Tremaine, Ali A Fouladi-Nashta

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