Abstract
Osteopontin (OPN) and osteoprotegerin (OPG) are bone metabolism biomarkers potentially associated with nerve function. We evaluated the association of cardiovascular autonomic nerve function, OPN, and OPG in 50 individuals with type 2 diabetes mellitus (T2DM). RR-variation during deep breathing (i.e., mean circular resultant (MCR) and expiration/inspiration (E/I) ratio) was used to assess parasympathetic nerve function. Participants' demographics, HbA1c, 25-hydroxyvitamin D (25(OH)D), BMI, HOMA-IR, calcium, parathyroid hormone, creatinine, OPN, and OPG were determined. Using stepwise multiple linear regression analysis with MCR or E/I ratio as the dependent variable, OPN was independently associated with reduced autonomic function. A previous report showed a significant association of cardiovascular autonomic function with age, 25(OH)D insufficiency, and the interaction of age×25(OH)D insufficiency. Here we report a novel association for OPN and its interaction with age indicating that for those who are younger, elevated OPN levels are related to a greater loss of autonomic function (MCR model R2=0.598, p<0.001; E/I model R2=0.594, p<0.001). Our results suggest that OPN is associated with reduced parasympathetic function, parti...Continue Reading
References
Feb 5, 1999·Circulation Research·T WadaC M Giachelli
Jan 10, 2002·Journal of Neuroscience Research·Sebastian JanderGuido Stoll
Feb 9, 2002·QJM : Monthly Journal of the Association of Physicians·M MazzaliJ Hughes
Jun 26, 2003·European Journal of Endocrinology·S T KnudsenL M Rasmussen
Sep 5, 2003·Journal of Diabetes and Its Complications·Raelene E Maser, M James Lenhard
Jan 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Robert MellerMary P Stenzel-Poore
Sep 27, 2005·Current Neurovascular Research·Oleksandr Ekshyyan, Tak Yee Aw
Jun 28, 2007·The Journal of Clinical Endocrinology and Metabolism·Javier Gómez-AmbrosiGema Frühbeck
Aug 2, 2008·Clinics in Geriatric Medicine·Aaron I VinikChhaya V Patel
Dec 5, 2008·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H M TerekeciM Ozata
Jun 12, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·M NyboL M Rasmussen
May 5, 2011·Clinical Biochemistry·Ewa StępieńMieczysław Pasowicz
Apr 13, 2012·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Savas GuzelAslan Celebi
May 4, 2012·Cellular and Molecular Neurobiology·Toshihiko SuzukiHiroyuki Ichikawa
May 30, 2012·International Journal of Cardiology·Dimitris TousoulisChristodoulos Stefanadis
Apr 4, 2013·Journal of Diabetes Investigation·Aaron I VinikCarolina M Casellini
Feb 1, 2012·Translational Neuroscience·Amanda Brown
Jul 23, 2013·European Journal of Pharmacology·P Sytze Van DamNorman E Cameron
Jan 31, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megan C WrightAhmet Höke
Feb 26, 2014·World Journal of Diabetes·Gerasimos DimitropoulosMartin J Stevens
Jul 10, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·S TavintharanSum Chee Fang
Jul 12, 2014·The Journal of Clinical Endocrinology and Metabolism·Olivier BourronAgnès Hartemann
Aug 8, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Raelene E MaserRyan T Pohlig
Oct 10, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Raelene E MaserRyan T Pohlig
Citations
Jul 10, 2018·Ophthalmic Epidemiology·Barbara E K KleinRonald Klein
Jul 13, 2018·Diabetic Medicine : a Journal of the British Diabetic Association·C S HansenP Rossing
Feb 12, 2020·The International Journal of Lower Extremity Wounds·Ioanna EleftheriadouNikolaos Tentolouris
Jun 24, 2017·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Raelene E MaserP Babu Balagopal
Nov 6, 2018·Cell & Bioscience·Fei LiuJing Lan
Sep 3, 2020·Medicine·Jianhua WuDongfang Wu
Oct 22, 2020·BMC Cardiovascular Disorders·M R JasmineG K Pal