Osteopontin as a Link between Inflammation and Cancer: The Thorax in the Spotlight

Cells
Anne-Sophie LamortGeorgios T Stathopoulos

Abstract

The glycoprotein osteopontin (OPN) possesses multiple functions in health and disease. To this end, osteopontin has beneficial roles in wound healing, bone homeostasis, and extracellular matrix (ECM) function. On the contrary, osteopontin can be deleterious for the human body during disease. Indeed, osteopontin is a cardinal mediator of tumor-associated inflammation and facilitates metastasis. The purpose of this review is to highlight the importance of osteopontin in malignant processes, focusing on lung and pleural tumors as examples.

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Methods Mentioned

BETA
bronchoalveolar
enzyme-linked immunosorbent assay

Clinical Trials Mentioned

NCT03270358
NCT03561285

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