PMID: 11926891Apr 3, 2002Paper

Osteopontin as a potential diagnostic biomarker for ovarian cancer

JAMA : the Journal of the American Medical Association
Jae-Hoon KimSamuel C Mok

Abstract

Development of new biomarkers for ovarian cancer is needed for early detection and disease monitoring. Analyses involving complementary DNA (cDNA) microarray data can be used to identify up-regulated genes in cancer cells, whose products may then be further validated as potential biomarkers. To describe validation studies of an up-regulated gene known as osteopontin, previously identified using a cDNA microarray system. Experimental and cross-sectional studies were conducted involving ovarian cancer and healthy human ovarian surface epithelial cell lines and cultures, archival paraffin-embedded ovarian tissue collected between June 1992 and June 2001, and fresh tissue and preoperative plasma from 144 patients evaluated for a pelvic mass between June 1992 and June 2001 in gynecologic oncology services at 2 US academic institutions. Plasma samples from 107 women selected from an epidemiologic study of ovarian cancer initiated between May 1992 and March 1997 were used as healthy controls. Relative messenger RNA expression in cancer cells and fresh ovarian tissue, measured by real-time polymerase chain reaction as 2(-DeltaDeltaCT)(a quantitative value representing the amount of osteopontin expression); osteopontin production, local...Continue Reading

Citations

Mar 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·John B WelshGarret M Hampton
Jun 1, 2008·Biomarkers in Medicine·Partha M Das, Robert C Bast
Sep 11, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Daniel H PooleJoy L Pate
Aug 18, 2009·Biomarkers in Medicine·Dimitra SasaroliNathalie Scholler
Dec 17, 2009·Future Oncology·Ie-Ming Shih, Ben Davidson
Jul 16, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Katie L MeehanAndrew N Stephens
May 14, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gil MorDavid C Ward
Oct 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Katherine R KozakRobin Farias-Eisner
Jul 10, 2010·Journal of Neuro-oncology·Anja ElstnerAndreas Kurtz
Jun 11, 2014·Medical Oncology·Jun-li WangChun-fang Wang
Dec 17, 2008·Women's Health·Celestine S TungSamuel C Mok
Mar 13, 2013·Women's Health·Long NguyenDavid Fishman
Apr 15, 2004·Molecular and Cellular Biology·Dawei LiThomas Benjamin
Oct 17, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Pi-Ling ChangKang-Jey Ho
Aug 22, 2009·Journal of Oncology·Daris FerrariPaolo Foa
Jul 1, 2007·Annals of Thoracic Medicine·Ayman BishayMichael Baumann
Jan 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Justin D BlasbergJessica S Donington
Feb 26, 2010·BMC Cancer·Narasimhan KothandaramanMahesh Choolani
Aug 14, 2010·Journal of the National Cancer Institute·Eleftherios P Diamandis
Dec 22, 2010·Journal of Translational Medicine·Nicole HaverlandPawel Ciborowski
Jan 25, 2013·International Journal of Molecular Sciences·Dominic VargaLisa Wiesmüller
May 15, 2007·International Journal of Epidemiology·Hyoung Doo ShinHyo-Suk Lee
Sep 5, 2002·Nature Reviews. Drug Discovery·Emanuel F PetricoinLance A Liotta
Jul 30, 2009·The Tohoku Journal of Experimental Medicine·Haorile Chagan-YasutanToshio Hattori
Nov 2, 2012·Genetic Testing and Molecular Biomarkers·Sharmila VelapasamyLian Wee Ler
Aug 17, 2005·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ruth A Pyle-ChenaultJiangchun Xu
Apr 9, 2005·Bioinformatics·Jane Jijun LiuXuefeng Bruce Ling
Jan 15, 2004·Drug Discovery Today·Priti S HegdeChristine Debouck
Jun 18, 2002·Trends in Molecular Medicine·Robert S NegmSudhir Srivastava
Jan 14, 2003·Trends in Molecular Medicine·Garret M Hampton, Henry F Frierson
Apr 23, 2004·Trends in Molecular Medicine·Emanuel F Petricoin, Lance A Liotta
Jun 22, 2005·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Juliane BrieseA M Bamberger
Apr 25, 2006·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Juliane BrieseAna-Maria Bamberger
Jan 16, 2007·Journal of Biomedical Science·Li Hong BaoTeruhiko Tamaya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.