Osteopontin-expressing macrophages in non-small cell lung cancer predict survival

The Annals of Thoracic Surgery
Yue LiChang-Li Wang

Abstract

Tumor-associated macrophages (TAMs) are a major component of leukocyte infiltration in the tumor microenvironment. Osteopontin is related to tumor metastasis and proliferation. Osteopontin is expressed not only by tumor cells but also by TAMs. The purpose of the current study was to assess the prognostic significance of osteopontin expressed by TAMs (TOPN) in patients with non-small cell lung cancer. Tissue microarray was used to detect the expression of TOPN, TAMs, and microvascular density in 159 patients with non-small cell lung cancer undergoing complete pulmonary resection in our hospital between 2003 and 2006. The correlations between TOPN, TAMs, and clinicopathologic data were analyzed with χ(2) tests. Quantitation of TAMs or TOPN and microvascular density analyses was performed using Bonferroni correction and the Student's t test. The prognostic value of TOPN was evaluated by univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazard model analysis. In the recurrence and metastasis group, microvascular density was higher than that in the control group (14.4 ± 1.06 versus 8.9 ± 1.02; p = 0.0002). In the TOPN-positive group, microvascular density was increased compared with that in the TOPN-negativ...Continue Reading

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Citations

Mar 10, 2016·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Ying SunXian-Dong Li
May 4, 2016·Oncoimmunology·Gerhard HamiltonMaximilan J Hochmair
Apr 7, 2015·The Annals of Thoracic Surgery·Mara Antonoff
Nov 20, 2019·Carcinogenesis·Ioanna GiopanouIoannis Psallidas
Nov 17, 2020·Frontiers in Oncology·Irina LarionovaJulia Kzhyshkowska
Nov 19, 2020·Cancers·Hannah R MoormanKebin Liu
Mar 5, 2021·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Umar MehrajManzoor A Mir
Mar 16, 2021·Frontiers in Oncology·Claire Deligne, Kim S Midwood

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