Osteopontin expression in reactive lesions of gingiva

Journal of Applied Oral Science : Revista FOB
Rathinam ElanagaiRamdas Madhavan Nirmal

Abstract

Reactive proliferations of the gingiva comprise lesions such as pyogenic granuloma (PG), inflammatory fibroepithelial hyperplasia (IFH), peripheral ossifying fibroma (POF), and peripheral giant cell lesion. Osteopontin (OPN) has a dual role, it promotes mineralization when it is bound to solid substrate, and on the other hand, it inhibits mineralization when it is seen in association with solution. Objectives The study aimed to evaluate the expression of osteopontin in normal gingival tissue and different types of focal reactive proliferations of gingival tissue, and its role in the development of calcification within it. Material and Methods The presence and distribution of osteopontin was assessed using immunohistochemistry in five cases of normal gingival tissue and 30 cases of focal reactive proliferations of gingiva. Results There was no expression of osteopontin in normal subjects. Few cases of pyogenic granuloma, inflammatory fibroepithelial hyperplasia, and all the cases of peripheral ossifying fibroma showed positivity for osteopontin in the inflammatory cells, stromal cells, extracellular matrix, and in the calcifications. Conclusion The expression of osteopontin in all the cases of peripheral ossifying fibroma specul...Continue Reading

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Citations

Dec 23, 2016·Journal of Clinical Periodontology·Yun Wang, Dimitris N Tatakis
Jul 26, 2017·Laser Therapy·Nitesh TewariDivesh Sardana
Aug 20, 2021·Journal of Maxillofacial and Oral Surgery·Shilpa Sunil KhannaSudhakar Srinivasan
Oct 1, 2021·Clinical Advances in Periodontics·Anat Katorza, Jacob Horwitz

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