Osteopontin-induced brown adipogenesis from white preadipocytes through a PI3K-AKT dependent signaling

Biochemical and Biophysical Research Communications
Xiao-Juan ZhongQi-Ren Huang

Abstract

Recent studies have shown that OPN (osteopontin) plays critical roles in cell survival, differentiation, bio-mineralization, cancer and cardiovascular remodeling. However, its roles in the differentiation of brown adipocytes and the underlying mechanisms remain unclear. Therefore, the aim of this study was to investigate the roles of OPN in the brown adipogenesis and the underlying mechanisms. It was shown that the OPN successfully induced the differentiation of 3T3-L1 white preadipocytes into the PRDM16(+) (PRD1-BF1-RIZ1 homologous domain containing 16) and UCP-1(+) (uncoupling protein-1) brown adipocytes in a concentration and time-dependent manner. Also, activation of PI3K (phosphatidylinositol 3-kinase)-AKT pathway was required for the OPN-induced brown adipogenesis. The findings suggest OPN plays an important role in promoting the differentiation of the brown adipocytes and might provide a potential novel therapeutic approach for the treatment of obesity and related disorders.

References

Jan 3, 2001·European Journal of Pharmacology·E Ravussin, C Bouchard
Jan 15, 2003·Experimental Physiology·Martin Klingenspor
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Sep 2, 2005·Molecular and Cellular Biology·Bingzhong XueLeslie P Kozak
Jul 10, 2007·Cell Metabolism·Patrick SealeBruce M Spiegelman
May 17, 2008·Genes & Development·Stephen R Farmer
May 17, 2008·Genes & Development·Shingo KajimuraBruce M Spiegelman
Sep 9, 2008·The Journal of Biological Chemistry·Mengwei ZangZhijun Luo
Mar 17, 2009·Biochemical and Biophysical Research Communications·Jianxin DaiYajun Guo
May 8, 2009·The New England Journal of Medicine·Sven Enerbäck
Jul 1, 2009·Diabetes·Patrick Seale, Mitchell A Lazar
Jul 4, 2009·Journal of Molecular and Cellular Cardiology·Mahipal SinghKrishna Singh
Oct 3, 2009·Journal of Cell Communication and Signaling·Susan Amanda LundMarta Scatena
Oct 24, 2009·Experimental Cell Research·Brian W Robertson, Meenakshi A Chellaiah
Nov 10, 2009·Cytokine & Growth Factor Reviews·Tim J Schulz, Yu-Hua Tseng
Jan 14, 2010·Journal of Cellular Biochemistry·Ting ZhangKaiping Yang
Feb 25, 2010·Apoptosis : an International Journal on Programmed Cell Death·Qi-Ren HuangMing He
May 8, 2010·Science·Jeff Ishibashi, Patrick Seale
Dec 3, 2010·The Journal of Clinical Investigation·Patrick SealeBruce M Spiegelman
Apr 26, 2011·Journal of Cell Communication and Signaling·Pieter H AnborghAnn F Chambers
Dec 20, 2011·The Journal of Biological Chemistry·Brian ChristensenEsben S Sørensen
Feb 3, 2012·Nature Cell Biology·Andrew G Elefanty, Edouard G Stanley
Aug 31, 2013·Developmental Cell·Jun Hong ParkSean Bong Lee
Dec 20, 2015·Journal of Cellular Biochemistry·David E LeeNicholas P Greene

❮ Previous
Next ❯

Citations

Jul 5, 2016·International Journal of Molecular Sciences·Francisco Javier Ruiz-OjedaConcepción María Aguilera
Nov 7, 2018·Journal of Cellular and Molecular Medicine·Ying KongQiren Huang
Dec 2, 2020·Animals : an Open Access Journal From MDPI·Jiahao ShaoSongjia Lai
Apr 11, 2021·Archives of Physiology and Biochemistry·Lokanatha OrugantiBalaji Meriga

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Acute viral rhinopharyngitis

Acute viral rhinopharyngitis, also known as "common cold", is an acute, self-limiting viral infection of the upper respiratory tract involving the nose, sinuses, pharynx and larynx. Discover the latest research on acute viral rhinopharyngitis here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.