Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice

Developmental Dynamics : an Official Publication of the American Association of Anatomists
Gamze KilicBeatriz Sosa-Pineda

Abstract

Matricellular proteins mediate both tissue morphogenesis and tissue homeostasis in important ways because they modulate cell-matrix and cell-cell interactions. In this study, we found that the matricellular protein osteopontin (Opn) is a novel marker of undifferentiated pancreatic precursors and pancreatic ductal tissues in mice. Our analysis also underscored a specific, dynamic profile of Opn expression in embryonic pancreatic tissues that suggests the participation of this protein's function in processes involving cell migration, cell-cell interactions, or both. Surprisingly, our analysis of Opn-deficient pancreata did not reveal obvious alterations in the morphology or differentiation of these tissues. Therefore, in embryonic pancreatic tissues, it is possible that other proteins act redundantly to Opn or that this protein's function is dispensable for pancreas development. Finally, the maintenance of Opn expression in pancreatic tissues of adults argues for a possible function of this protein in injury and pathologic responses.

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Citations

Oct 25, 2012·In Vitro Cellular & Developmental Biology. Animal·Julie A RhodesFarzad Esni
Feb 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Liang JinHsun Teresa Ku
Aug 20, 2008·Molecular and Cellular Biology·Cécile HaumaitreRaphaël Scharfmann
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Oct 19, 2019·International Journal of Molecular Sciences·Ilaria GuerrieroGeppino Falco
May 2, 2020·Proceedings of the National Academy of Sciences of the United States of America·Mirza Muhammad Fahd QadirJuan Domínguez-Bendala
Jun 24, 2019·Cellular and Molecular Gastroenterology and Hepatology·Evans QuilichiniCécile Haumaitre

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