Osteoporoses: a rationale for further definitions?

Calcified Tissue International
Harold M Frost

Abstract

Bone's biologic mechanisms adapt it to meet the needs of its mechanical usage and muscle strength. Modeling by drifts can increase bone strength and "mass," BMU-based remodeling can conserve or reduce them, and neither can do the other's work. Under increasing forces on bone, modeling increases bone strength and "mass" and remodeling maintains the extra bone. In disuse, modeling turns OFF and remodeling reduces bone strength and "mass" to cause osteopenia. Osteopenia increases bone fragility as does bone microdamage, and they can coexist. Too little bone for one's mechanical usage and muscle strength can cause spontaneous fractures and/or bone pain. The bone-loss and tissue-dynamic patterns in acute and chronic disuse strongly copy the patterns in developing and established osteopenias in known medical conditions. Such things suggest that at least three osteoporosis variants can occur: (1) in physiologic osteopenias, bone strength and "mass" would decrease to correspond to reduced muscle strength and physical activity so that spontaneous fractures and bone pain would not occur. An intrinsic bone disorder would not cause this osteopenia, and fractures would only follow injuries, usually of extremity bones. (2) In "true osteoporo...Continue Reading

Citations

Dec 24, 2002·Research Quarterly for Exercise and Sport·Vicki M PittengerDavid Q Thomas
Sep 13, 2012·Implant Dentistry·Pablo Galindo-MorenoFrancisco O'Valle
Oct 23, 1997·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H M Frost
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Mar 23, 2010·Aging Clinical and Experimental Research·Dmitry ManevichAvital Hershkovitz
Aug 10, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J C ChengX Guo
Dec 30, 2006·Endocrinology·Daniel S PerrienDana Gaddy
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