PMID: 28530076May 23, 2017Paper

OSTEOPOROSIS AND DIABETES - IN WHICH WAY ARE THEY RELATED?

Harefuah
Osnat Tell-Lebanon, Pnina Rotman-Pikielny

Abstract

Diabetes and osteoporosis are common diseases with growing prevalence in the aging population. Many recent studies have reported an association between diabetes mellitus and an increased osteoporotic fracture rate. Compared to control subjects, decreased bone mineral density has been observed in patients with type 1 diabetes mellitus, while those with type 2 diabetes display a unique skeletal phenotype of increased bone mineral density, but impaired architectural structure and mineral properties. Accumulation of advanced glycation end products changes collagen structure and suppression of bone turnover causes impairment of repair and adaptation mechanisms. These seem to be significant factors impairing bone strength. In addition, longer disease duration, disease complications, insulin use and increased falls, as well as the use of drugs like thiazolidinediones for treatment, are all reported risk factors for fractures among patients with diabetes. Conventional diagnostic tools, including DXA measurements and the fracture risk assessment (FRAX) tool, seem to underestimate fracture risk so that for every FRAX, the actual risk of fracture is higher in the diabetic patient. Despite the unique pathophysiology of bone disease in pati...Continue Reading

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

Related Papers

Metabolism: Clinical and Experimental
Anastasia D DedeGeorge Trovas
Current Osteoporosis Reports
Ling OeiEdwin H G Oei
Nihon rinsho. Japanese journal of clinical medicine
Ryo Okazaki
Nihon rinsho. Japanese journal of clinical medicine
Ippei Kanazawa
The Lancet. Diabetes & Endocrinology
Vikram V ShanbhogueMary L Bouxsein
© 2022 Meta ULC. All rights reserved