Osteoporosis and trace elements--an overview

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Jan AasethOle Andersen

Abstract

More than 200 million people are affected by osteoporosis worldwide, as estimated by 2 million annual hip fractures and other debilitating bone fractures (vertebrae compression and Colles' fractures). Osteoporosis is a multi-factorial disease with potential contributions from genetic, endocrine functional, exercise related and nutritional factors. Of particular considerations are calcium (Ca) status, vitamin D, fluoride, magnesium and other trace elements. Several trace elements such as zinc and copper are essential for normal development of the skeleton in humans and animals. Fluoride accumulates in new bone and results in a net gain in bone mass, but may be associated with a tissue of poor quality. Aluminum induces impairment of bone formation. Gallium and cadmium suppresses bone turnover. However, exact involvements of the trace elements in osteoporosis have not yet been fully clarified. Numerous investigators have evaluated the role of medications and supplementations with minerals and trace substances to reverse the progression of this disease. Although bisphosphonates are still the drugs of choice, low-dosed fluoride and strontium salts have shown promise for the future.

References

Jan 1, 1992·Calcified Tissue International·B J AbelowK L Insogna
Feb 1, 1991·Environmental Health Perspectives·J G PoundsJ F Rosen
Jun 1, 1988·Annals of Internal Medicine·G P DalskyS J Birge
Jun 1, 1986·Metabolism: Clinical and Experimental·P J Marie, M Hott
Sep 18, 1981·Science·W Mertz
Aug 1, 1993·Journal of the American College of Nutrition·P D Saltman, L G Strause
Jan 1, 1996·The Journal of Clinical Endocrinology and Metabolism·B A Dure-SmithD J Baylink
Sep 1, 1995·Trends in Endocrinology and Metabolism : TEM·C Y PakP Antich
Dec 3, 2005·The Journal of Clinical Investigation·Lawrence G Raisz
Jun 10, 2006·Molecular Genetics and Metabolism·Qing-Yang Huang, Annie Wai Chee Kung

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Citations

Oct 12, 2012·Endocrine·Tiziana MontalciniArturo Pujia
Sep 3, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Sara PasqualettiMassimo Mariotti
Sep 7, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M P Hage, G El-Hajj Fuleihan
Nov 30, 2013·Biological Trace Element Research·Cecilie DahlUNKNOWN Norwegian Epidemiologic Osteoporosis Study (NOREPOS) Core Research Group
Nov 13, 2014·The Journal of Nutrition, Health & Aging·L F RodellaR Rezzani
Sep 16, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Per M Roos
Jan 1, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Mariangela RondanelliMilena Anna Faliva
Dec 15, 2015·Chemico-biological Interactions·Xudong SunYanfei Li
Feb 18, 2015·Proteomics. Clinical Applications·Ulrika QundosJochen M Schwenk
Apr 5, 2013·Journal of Biomedical Materials Research. Part a·Gerald ZimmerOskar Hoffmann
Jan 11, 2016·Journal of Biomedical Materials Research. Part a·Yingying ZhangYubo Fan
Sep 21, 2015·European Journal of Nutrition·Ayse ZenginMaximilian Bielohuby
Aug 26, 2015·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Michael DermiencePhilippe Goyens
Jul 15, 2015·Journal of Exposure Science & Environmental Epidemiology·Tsung-Lin TsaiShu-Li Wang
Jul 31, 2013·Bone·Erika Grasiela Marques de Menezes BarbosaAnderson Marliere Navarro
Mar 8, 2014·Journal of Diabetes and Metabolic Disorders·Rezvan RazmandehDavood Khoda-Amorzideh
Apr 10, 2015·PloS One·Sabra I DjomehriSunita P Ho
Jun 5, 2016·Biological Trace Element Research·Miao SongLi Gao
Jul 10, 2016·Biological Trace Element Research·Yilin LiaoCaiying Zhang
Jun 20, 2013·Gastroenterology Research and Practice·Jun IwamotoHideo Matsumoto
Oct 25, 2016·Environmental Toxicology and Pharmacology·Yanzhu ZhuYanfei Li
Nov 11, 2016·Biological Trace Element Research·Wanyue HuangYanzhu Zhu
Jun 8, 2017·International Journal of Environmental Research and Public Health·Luis M Puerto-ParejoJose M Moran
May 24, 2018·International Journal of Environmental Research and Public Health·Diana CabreraKarl Fraser
Oct 14, 2017·Biological Trace Element Research·Feibo XuYanfei Li
Jun 18, 2019·International Forum of Allergy & Rhinology·Hyo Geun Choi, Gyu Kong
Jul 7, 2017·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Fiona Jackson CookSuzanne Hudson
Aug 9, 2018·Journal of Clinical Biochemistry and Nutrition·Yu MatsumotoYoshiko Ishimi

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