Osteoporosis in ankylosing spondylitis - prevalence, risk factors and methods of assessment.

Arthritis Research & Therapy
Eva KlingbergHelena Forsblad-D'Elia

Abstract

Osteoporosis can be a complication of ankylosing spondylitis (AS), but diagnosing spinal osteoporosis can be difficult since pathologic new bone formation interferes with the assessment of the bone mineral density (BMD). The aims of the current study were to investigate prevalence and risk factors for reduced BMD in a Swedish cohort of AS patients, and to examine how progressive ankylosis influences BMD with the use of dual-energy x-ray absorptiometry (DXA) of the lumbar spine in different projections. Methods of assessment were questionnaires, back mobility tests, blood samples, lateral spine radiographs for syndesmophyte grading (mSASSS), DXA of the hip, radius and lumbar spine in anteroposterior (AP) and lateral projections with estimation of volumetric BMD (vBMD). AS patients (modified New York criteria), 87 women and 117 men, mean age 50 ± 13 years and disease duration 15 ± 11 years were included. According to World Health Organization (WHO) criteria 21% osteoporosis and 44% osteopenia was diagnosed in patients > = 50 years. Under age 50 BMD below expected range for age was found in 5%. Interestingly lateral lumbar DXA showed significantly lower BMD and revealed significantly more cases with osteoporosis as compared with A...Continue Reading

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Aug 14, 2013·BMC Musculoskeletal Disorders·Helena Forsblad-d'EliaLennart Bergfeldt
May 24, 2014·Calcified Tissue International·Jun BaoYi-Xiao Bao
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Jun 17, 2014·The Journal of Rheumatology·Eva KlingbergHelena Forsblad-d'Elia
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Jul 2, 2020·BMC Musculoskeletal Disorders·Zhuoran HuZhiming Lin

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Methods Mentioned

BETA
ESR
biopsies

Software Mentioned

PASW Statistics

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